[1]王玉珍,吴逸明,李伟辉,等.热休克蛋白70hom基因+2 437(T/C)位点基因多态性与肺癌的关系*[J].郑州大学学报(医学版),2010,(02):219-221.
 WANG Yuzhen,WU Yiming,LI Weihui,et al.Heat shock protein 70hom gene+2 437(T/C) polymorphism and susceptibility to lung cancer in Chinese Han population[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):219-221.
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热休克蛋白70hom基因+2 437(T/C)位点基因多态性与肺癌的关系*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年02期
页码:
219-221
栏目:
论著
出版日期:
2010-03-30

文章信息/Info

Title:
Heat shock protein 70hom gene+2 437(T/C) polymorphism and susceptibility to lung cancer in Chinese Han population
作者:
王玉珍 吴逸明 李伟辉 梁守沛 周舫#
郑州大学公共卫生学院劳动卫生学教研室郑州450001
Author(s):
WANG Yuzhen WU Yiming LI Weihui LIANG Shoupei ZHOU Fang
Department of Occupational Health, College of Public Health, Zhengzhou University, Zhengzhou 450001
关键词:
热休克蛋白70hom基因多态性肺癌
Keywords:
heat shock protein 70hom gene polymorphism lung cancer
分类号:
R734.2
文献标志码:
A
摘要:
研究热休克蛋白(HSP)70hom基因+2437(T/C)单核苷酸多态性与肺癌遗传易感性的关系,探讨肺癌易感的HSP70hom基因型。方法:应用聚合酶链反应限制性片段长度多态性(PCRRFLP)方法检测159例肺癌患者和202名正常对照人群HSP70hom基因+2437(T/C)位点多态性,采用病例对照研究分析其与肺癌的关系。结果:病例组与对照组之间HSP70hom各基因型(TT、TC和CC)频率及T和C的等位基因频率分布,差异均有统计学意义(P<0.05)。对病理类型分层分析并经年龄、性别、吸烟状况、饮酒史和肿瘤家族史调整后发现,非TT基因型携带者患肺鳞癌危险性是TT基因型携带者的2.17倍(95%CI:1.17~4.00)。对吸烟状况进行分层分析并经年龄、性别、饮酒史、肿瘤家族史调整后发现,吸烟者及重度吸烟者中非TT基因型调整OR值分别为5.19(95%CI:1.57~17.19)和9.23(95%CI:2.52~33.84),与肺癌有强关联,提示TT基因型是吸烟者特别是重度吸烟者的保护因素。结论:HSP70hom基因+2437(T/C)位点TT基因型可能是肺鳞癌的遗传保护因素,并可降低吸烟者特别是重度吸烟者患肺癌的危险度。
Abstract:
To investigate the correlation between the heat shock protein 70hom gene polymorphism and lung cancer.Methods:A casecontrol study of 159 lung cancer patients and 202 control subjects was carried out to investigate the relationship between the polymorphisms of HSP70hom gene+2 437 site and lung cancer. The genotype frequencies wasidentified by polymerase chain reactionrestriction fragment length polymorphism(PCRRFLP).Results:Significant differences were found in the distribution of HSP70hom genotypes and allele frequencies between lung cancer patients and controls(P<0.05). After stratified analysis of pathological types and adjusting by age, gender, smoking history, drinking status and family history, it was revealed that nonTT genotype was associated with increased risk of lung squamous cell carcinoma,OR=2.17(95%CI:1.17~4.00). After stratified analysis of smoking history and adjusting by age, gender, drinking status and family history, it was revealed that nonTT genotype was associated with increased risk of lung cancer in smokers group and heavysmokers group,OR=5.19(95%CI:1.57~17.19) and 9.23(95%CI:2.52~33.84).Conclusion: HSP70hom+2 437(T/C) TT genotype may act as a protective factor in lung squamous cell carcinoma patients and may decrease the risk of lung cancer in smokers group, especially in heavysmokers group.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目30600490,30571552;河南省教育厅科技创新人才支持计划2008HASTIT028;河南省教育厅自然科学研究资助项目2008A320018#通讯作者,女,1974年生,博士,副教授,研究方向:职业肿瘤及应激医学,Email:zhoufang23@sina.com
更新日期/Last Update: 2010-04-29