[1]马洪涛△,史艳平,封全灵.卵巢上皮性癌组织中磷酸化信号转导及转录活化因子3和Ki67蛋白的表达[J].郑州大学学报(医学版),2010,(02):246-248.
 MA Hongtao,SHI Yanping,FENG Quanling.Expression of psignal transducers and activators of transcription3 and Ki67 in epithelial ovarian carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):246-248.
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卵巢上皮性癌组织中磷酸化信号转导及转录活化因子3和Ki67蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年02期
页码:
246-248
栏目:
论著
出版日期:
2010-03-30

文章信息/Info

Title:
Expression of psignal transducers and activators of transcription3 and Ki67 in epithelial ovarian carcinoma tissue
作者:
马洪涛△史艳平封全灵
郑州大学第三附属医院妇产科郑州450052
Author(s):
MA Hongtao SHI YanpingFENG Quanling
Department of Gynecology and Obstetrics,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
卵巢上皮性肿瘤磷酸化信号转导及转录活化因子3Ki67细胞增殖
Keywords:
epithelial ovarian neoplasmcarcinoma pSTAT3 Ki67cell proliferation
分类号:
R737.31
文献标志码:
A
摘要:
检测卵巢上皮性癌组织中磷酸化信号转导及转录活化因子3(pSTAT3)和Ki67蛋白的表达。方法:应用免疫组织化学SP法检测35例卵巢上皮性癌组织(高分化11例,中分化12例,低分化12例;Ⅰ、Ⅱ期16例,Ⅲ、Ⅳ期19例;有淋巴结转移20例,无淋巴结转移15例)、20例良性卵巢上皮性肿瘤组织及30例正常卵巢组织中pSTAT3和Ki67蛋白的表达。结果:正常卵巢组织、良性卵巢上皮性肿瘤组织及卵巢上皮性癌组织中pSTAT3的表达水平分别为(43.20±3.18),(50.12±4.36)及(92.57±5.26),3者相比,差异有统计学意义(F=7.605,P=0.001);Ki67的表达水平分别为(7.69±1.21)、(12.53±2.62)及(16.18±5.32),3者相比,差异有统计学意义(F=3.925,P=0.029)。卵巢上皮性癌组织中pSTAT3和Ki67的表达与临床分期、分化程度及淋巴结转移有关(pSTAT3:t/F=6.921、3.865和7.763,P均<0.05;Ki67:t/F=6.917、3.870和4.021,P均<0.05)。卵巢上皮性癌组织中pSTAT3与Ki67的表达呈正相关(rS=0.563,P<0.001)。结论:卵巢上皮性癌组织中pSTAT3与Ki67的表达升高,联合检测2者对判断卵巢上皮性癌的恶性程度和预后有一定价值。
Abstract:
To detect the expressions of psignal transducers and activators of transcription3(STAT3) and Ki67 in epithelial ovarian carcinoma tissue.Methods:The expressions of pSTAT3 and Ki67 in normal ovary(n=30), benign epithelial ovarian tumor(n=20), and epithelial ovarian carcinoma tissue(n=35;11 cases of well differentiation,12 cases of moderate differentiation,and 12 cases of poor differentiation;16 cases of stage Ⅰ and Ⅱ,19 cases of stage Ⅲ and Ⅳ;20 cases with lymph node metastasis, 15 cases without lymph node metastasis) were detected by immunohistochemistry.Results: There was significant difference in the expressions of pSTAT3[(43.20±3.18),(50.12±4.36),and (92.57±5.36)] and Ki67[(7.69±1.21),(12.53±2.62),and (16.18±5.32)] among the three kinds of tissue(F=7.605 and 3.925,P<0.05). The expressions of pSTAT3 and Ki67 in epithelial ovarian carcinoma tissue were related with clinical stage,differentiation grade, and lymph node metastasis (pSTAT3:t/F=6.921,3.865 and 7.763,P<0.05;Ki67:t/F=6.917,3.870 and 4.021,P<0.05). The expressions of pSTAT3 and Ki67 in epithelial ovarian carcinoma tissue were positively correlated (rS=0.563, P<0.001).Conclusion: The expressions of pSTAT3 and Ki67 increase in epithelial ovarian carcinoma tissue.Combined detection of the 2 parameters is of value in predicting the malignant degree and prognosis of epithelial ovarian carcinoma.

参考文献/References:

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备注/Memo

备注/Memo:
△男,1963年生,本科,副主任医师,研究方向:妇科肿瘤,Email:mahongtaohn@163.com
更新日期/Last Update: 2010-04-29