[1]王莹)△,马传根),徐靖宇),等.顺式阿曲库铵对大鼠骨骼肌复合动作电位的影响[J].郑州大学学报(医学版),2010,(02):275-277.
 WANG Ying),MA Chuangen),XU Jingyu),et al.Effects of cisatracurium on compound muscle action potential in rats[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):275-277.
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顺式阿曲库铵对大鼠骨骼肌复合动作电位的影响()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年02期
页码:
275-277
栏目:
论著
出版日期:
2010-03-30

文章信息/Info

Title:
Effects of cisatracurium on compound muscle action potential in rats
作者:
王莹1)马传根2)徐靖宇2)洪道先1)陈宗2)刘星2)
1)河南大学第一附属医院麻醉科开封4750012)河南大学淮河医院麻醉科开封475001
Author(s):
WANG Ying1)MA Chuangen2) XU Jingyu2) HONG Daoxian1)CHEN Zong2)LIU Xing2)
1)Department of Anesthesiology,the First Affiliated Hospital, Henan University, Kaifeng 4750012)Department of Anesthesiology,Huaihe Hospital,Henan University, Kaifeng 475001
关键词:
顺式阿曲库铵骨骼肌复合动作电位大鼠
Keywords:
cisatracuriumcompound muscle action potentialrat
分类号:
R971.2
文献标志码:
A
摘要:
观察肌松药顺式阿曲库铵对大鼠骨骼肌复合动作电位(CMAP)的影响。方法:32只大鼠随机分为2组,每组16只。实验组腹腔内注射顺式阿曲库铵(0.2mg/kg),对照组腹腔内注射等体积等渗生理盐水。于用药前及用药后每隔5min,刺激坐骨神经,于股二头肌记录CMAP,观察肌松药作用下CMAP潜伏期、波幅的变化规律。结果:2组间CMAP的潜伏期及波幅比较,差异均有统计学意义(潜伏期:F组间=8.654,P=0.010;F时间=6.753,P=0.030;波幅:F组间=6.634,P=0.030;F时间=7.134,P=0.020)。实验组CMAP变化可分为3个阶段:诱导期,表现为潜伏期逐渐延长,波幅逐渐下降,但与用药前相比,波幅下降幅度<50%,该期持续15~20min;抑制期,表现为潜伏期逐渐延长,CMAP波形消失或波幅下降,幅度>50%,该期持续10~15min;恢复期,表现为潜伏期逐渐缩短,波幅逐渐增高,直至恢复用药前水平,该期持续20~25min。结论:顺式阿曲库铵对CMAP的影响可分为诱导期、抑制期和恢复期3个阶段。为正确评价神经肌肉功能状况,术中肌电检测时应争取在恢复期(用药后40~45min)后进行。
Abstract:
To study the effects of cisatracurium on compound muscle action potential(CMAP) in rats.Methods:A total of 32 SD rats were divided into two groups. In the experiment group, cisatracurium (0.2 mg/kg)was given by intraperitoneal injection,and isotonic saline of the same volume was given to the control group. CMAP was recorded in the biceps following a stimulation at the sciatic nerve at different time, i.e. every 5 minutes before and after injection until it returned to normal. Latency and amplitude of CMAP were calculated and statistically analyzed.Results:There were significant differences in CMAP latency and amplitude between two groups (CMAP latency:Fgroup=8.654,P=0.010;Ftime=6.753,P=0.030;CMAP amplitude:Fgroup=6.634,P=0.030;Ftime=7.134,P=0.020). As to the experiment group, the changes of CMAP were divided into 3 stages. Induction stage:the latency was gradually delayed, and the amplitude reduced. But compared with normal CMAP,the amplitude reduction rate was below 50%. The stage lasted 15~20 minutes. Inhibition stage:CMAP was absent or the amplitude reduction rate was above 50%. The stage lasted 10~15 minutes. Restoration stage:the latency was gradually shortened. However, the amplitude increased to normal state. The stage lasted 20~25 minutes.Conclusion: The changes of CMAP under the effects of cisatracurium could be divided into induction, inhibition,and restoration stage. In order to correctly evaluate the function of neuromuscle, the intraoperative CMAP test should be performed after restoration stage (40~45 minutes after administration).

参考文献/References:

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[3]查燕萍,李金宝,邓小明,等.罗库溴铵和顺式阿曲库铵用于全麻诱导气管插管的效果比较[J].第二军医大学学报,2009,30(8):903
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备注/Memo

备注/Memo:
△女,1977年生,本科,主治医师,研究方向:临床麻醉学
更新日期/Last Update: 2010-04-29