[1]王涛)△,侯桂琴).食管鳞状细胞癌组织中Survivin与Caspase3蛋白的表达[J].郑州大学学报(医学版),2010,(03):362-365.
 WANG Tao),HOU Guiqin).Expressions of Survivin and Caspase3 proteins in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):362-365.
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食管鳞状细胞癌组织中Survivin与Caspase3蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年03期
页码:
362-365
栏目:
食管癌研究
出版日期:
2010-05-15

文章信息/Info

Title:
Expressions of Survivin and Caspase3 proteins in esophageal squamous cell carcinoma tissue
作者:
王涛1)侯桂琴2)
1)河南中医学院第一附属医院血液肿瘤科郑州4500002)郑州大学药学院郑州450001
Author(s):
WANG Tao1)HOU Guiqin2)
1)Department of Hematotumor, the First Affiliated Hospital,College of Traditional Chinese Medicine of Henan Province,Zhengzhou 4500002)College of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001
关键词:
SurvivinCaspase3食管肿瘤鳞状细胞癌凋亡
Keywords:
SurvivinCaspase3esophageal neoplasmsquamous cell carcinomaapoptosis
分类号:
R735.1
摘要:
检测人食管鳞状细胞癌组织中Survivin与Caspase3蛋白的表达情况。方法:采用免疫组织化学SP法检测60例食管鳞状细胞癌及60例正常食管黏膜组织中Survivin及Caspase3蛋白的表达情况,分析其与食管鳞状细胞癌临床病理特征的关系及2者表达的关联性。结果:食管鳞状细胞癌组织中Survivin蛋白的阳性表达率为51.7%(31/60),高于正常食管黏膜组织的8.3%(5/60)(χ2=26.825,P<0.001);且食管鳞状细胞癌组织中Survivin蛋白的阳性表达率与浸润深度 (χ2=8.721,P=0.003)和淋巴结转移情况(χ2=13.158,P<0.001)有关。食管鳞状细胞癌组织中Caspase3蛋白的阳性表达率为40.0%(24/60),低于正常食管黏膜组织的81.7%(49/60)(χ2=21.860,P<0.001);且食管鳞状细胞癌组织中Caspase3蛋白的阳性表达率与浸润深度(χ2=6.123,P=0.013)和淋巴结转移情况(χ2=5.884,P=0.015)有关。食管鳞状细胞癌组织中Survivin与Caspase3蛋白的表达有关联(χ2=5.384,rP=0.300,P=0.020)。结论:Survivin蛋白高表达、Caspase3蛋白低表达可能参与食管鳞状细胞癌的发生发展。
Abstract:
To detect the expressions of Survivin and Caspase3 in esophageal squamous cell carcinoma tissue.Methods:Immunohistochemical staining (SP method) was used to detect Survivin and Caspase3 expressions in 60 cases of esophageal squamous cell carcinoma and 60 cases of normal esophageal mucosa tissue.Results: Positive expression rate of Survivin was 51.7%(31/60) in esophageal squamous cell carcinoma tissue, while 8.3%(5/60) in normal mucosa tissue(χ2=26.825,P<0.001). And the Survivin positive expression rate of esophageal squamous cell carcinoma tissue was related with invasion depth(χ2=8.721,P=0.003) and lymph node metastasis (χ2=13.158,P<0.001). Positive expression rate of Caspase3 was 40.0%(24/60) in esophageal squamous cell carcinoma tissue, while 81.7%(49/60) in normal mucosa tissue(χ2=21.860,P<0.001).

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备注/Memo

备注/Memo:
△男,1979年4月生,硕士,主治医师,研究方向:肿瘤免疫,Email:zangwenqiao@sina.com
更新日期/Last Update: 2010-05-28