[1]张延新),刘喜民),陈奎生)#,等.胃癌组织中KISS1和基质金属蛋白酶9蛋白的表达*[J].郑州大学学报(医学版),2010,(03):384-386.
 ZHANG Yanxin),LIU Ximin),CHEN Kuisheng),et al.Expression of KISS1 and MMP9 in gastric carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):384-386.
点击复制

胃癌组织中KISS1和基质金属蛋白酶9蛋白的表达*()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年03期
页码:
384-386
栏目:
论著
出版日期:
2010-05-15

文章信息/Info

Title:
Expression of KISS1 and MMP9 in gastric carcinoma tissue
作者:
张延新1)刘喜民2)陈奎生3)#杜华贞1)张云汉3)
1)漯河医学高等专科学校病理学教研室漯河4620022)漯河医学高等专科学校组织胚胎学教研室漯河4620023)郑州大学基础医学院病理学教研室;河南省肿瘤病理重点实验室郑州450052
Author(s):
ZHANG Yanxin1) LIU Ximin2) CHEN Kuisheng3) DU Huazhen1) ZHANG Yunhan3)
关键词:
胃肿瘤KISS1基质金属蛋白酶9
Keywords:
gastric neoplasm carcinoma KISS1 MMP9
分类号:
R735.2
摘要:
检测胃癌组织中KISS1和基质金属蛋白酶9(MMP9)蛋白的表达。方法:应用免疫组织化学SP法分别检测45例胃癌组织及配对远离胃癌手术切缘的正常组织中KISS1和MMP9蛋白的表达。结果:胃癌组织及配对正常组织中KISS1蛋白的阳性表达率分别为35.6%(16/45)和88.9%(40/45),2者相比,差异有统计学意义(χ2=16.531,P<0.001);MMP9蛋白的阳性表达率分别为60.0%(27/45)和8.9%(4/45),2者相比,差异有统计学意义(χ2=17.926,P<0.001)。胃癌组织中KISS1和MMP9蛋白的表达均与胃癌浸润深度及有无淋巴结转移有关(χ2分别为9.652、5.670和9.050、5.351,P均<0.05)。胃癌组织中2者的表达有关联(rP =0.469,P<0.001)。结论:KISS1和MMP9的表达和胃癌的发生发展及浸润转移有关,联合检测2者有望用于胃癌的早期诊断和预后判断。
Abstract:
To detect the expression of KISS1 and MMP9 proteins in gastric carcinoma tissue.Methods:The expressions of KISS1 and MMP9 proteins in 45 cases of gastric carcinoma and matched normal gastric mucosa tissue were detected by using immunohistochemical SP method.Results: The positive expression rates of KISS1 protein in gastric carcinoma and normal gastric mucosa tissue were 35.6%(16/45) and 88.9%(40/45), respectively, and the difference was significant (χ2=16.531,P<0.001).

参考文献/References:

[1]Svensson A,Backman U,Fuchs D, et al. Angiogenesis can be reduced without significant reduction of tumor growth[J]. Anticancer Res,2007,27(6B):3 883
[2]王战会,冯笑山,王公平,等. KISS1和E钙黏蛋白在贲门癌组织中的表达及临床意义[J].中华胃肠外科杂志, 2007,10(4):380
[3]李晟磊,刘宗文,赵秋民,等.食管鳞癌组织中RECK mRNA和蛋白的表达及意义[J].中国肿瘤临床, 2007,34(22):1 280
[4]张淑兰,于艺,姜涛,等.卵巢上皮性癌组织中KISS1基因及其受体GPR54 mRNA的表达及其意义[J]. 中华妇产科杂志, 2005,40(10):689
[5]Kostadima L, Pentheroudakis G,Pavlidis N. The missing kiss of life: transcriptional activity of the metastasis suppressor gene KISS1 in early breast cancer[J]. Anticancer Res, 2007,27(4B):2 499
[6]Kotani M, Detheux M, Vandenbogaerde A, et al. The metastasis suppressor gene KISS1 encodes kisspeptins, the natural ligands of the orphan G proteincoupled receptor GPR54[J]. J Biol Chem, 2001,276(37):34 631
[7]Rao JS,Bhoopathi P,Chetty C,et al. MMP9 short interfering RNA induced senescence resulting in inhibition of medulloblastoma growth via p16(INK4a) and mitogenactivated protein kinase pathway[J].Cancer Res,2007,67(10):4 956
[8]温洪涛,张蕾,李继昌,等.人食管鳞癌组织中活性MMP2、MMP9的表达[J].郑州大学学报:医学版,2006,41(3):418
[9]Hori A, Honda S, Asada M, et al. Metastin suppresses the motility and growth of CHO cells transfected with its receptor[J]. Biochem Biophys Res Commun, 2001,286(5):958

相似文献/References:

[1]张威,陈玉,亚国伟,等.RNA干扰对EC9706细胞mTOR表达及细胞生长与凋亡的影响*[J].郑州大学学报(医学版),2010,(01):11.
 ZHANG Wei,CHEN Yu,YA Guowei,et al.Effect of mTOR siRNA on the expression of mTOR gene,growth and apoptosis of human esophageal carcinoma EC9706 cells[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):11.
[2]张弓,朱长举,宋燕,等.原发性肝细胞癌组织中EphA2和E钙黏素蛋白的表达[J].郑州大学学报(医学版),2010,(01):93.
 ZHANG Gong,ZHU Changju,SONG Yan,et al.Expression of EphA2 and Ecadherin in hepatocellular carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):93.
[3]王彦平),代丽萍),吴晓冰),等.细胞色素P4501A1 Ile/Val位点基因多态性与食管癌关系的meta 分析*[J].郑州大学学报(医学版),2010,(02):186.
 WANG Yanping),DAI Liping),WU Xiaobing),et al.Metaanalysis of cytochrome P4501A1 Ile/Val gene polymorphism with esophageal carcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):186.
[4]何卫华,史惠蓉#.卵巢上皮性癌组织中黏着斑激酶和肝癌缺失基因1 mRNA的表达*[J].郑州大学学报(医学版),2010,(02):209.
 HE Weihua,SHI Huirong.Expression of focal adhesion kinase and deleted in liver cancer 1 mRNA in epithelial ovarian cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):209.
[5]马洪涛△,史艳平,封全灵.卵巢上皮性癌组织中磷酸化信号转导及转录活化因子3和Ki67蛋白的表达[J].郑州大学学报(医学版),2010,(02):246.
 MA Hongtao,SHI Yanping,FENG Quanling.Expression of psignal transducers and activators of transcription3 and Ki67 in epithelial ovarian carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):246.
[6]罗执芬,周云#,刘明月.紫杉醇联合替尼泊苷对胃癌BGC823细胞增殖和凋亡的影响[J].郑州大学学报(医学版),2009,(05):942.
 LUO Zhifen,ZHOU Yun,LIU Mingyue.Effects of taxol and VM26 on proliferation and apoptosis of gastric cancer cell line BGC823[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):942.
[7]周云△,罗执芬.5氟尿嘧啶联合替尼泊苷对胃癌BGC823细胞增殖和凋亡的影响*[J].郑州大学学报(医学版),2009,(05):945.
 ZHOU Yun,LUO Zhifen.Effects of 5FU and VM26 on proliferation and apoptosis of gastric cancer cell line BGC823[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):945.
[8]周云)△,王晚萍).人重组p53腺病毒感染p53突变mBGC823细胞对顺铂敏感性的影响*[J].郑州大学学报(医学版),2009,(05):948.
 ZHOU Yun),WANG Wanping).Adenovirus mediated p53 gene enhances the sensitivity of gastric cancer cells containing mutanttype p53 to cisplatin[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):948.
[9]周云△.顺铂和5氟尿嘧啶联合替尼泊苷或依托泊甙治疗晚期胃癌疗效对比*[J].郑州大学学报(医学版),2009,(05):955.
 ZHOU Yun.Comparison of regimen VCF and ECF in treatment of advanced gastric cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):955.
[10]周云△.替尼泊苷和5氟尿嘧啶联合奥沙利铂或顺铂治疗晚期胃癌疗效对比[J].郑州大学学报(医学版),2009,(05):957.
 ZHOU Yun.Comparison of regimen VOF and VCF in treatment of advanced gastric cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):957.
[11]杨志浩),高剑波)#,陈奎生),等.螺旋CT诊断胃癌淋巴结转移的价值[J].郑州大学学报(医学版),2009,(06):1248.
 YANG Zhihao),GAO Jianbo),CHEN Kuisheng),et al.Spiral CT diagnostic value in lymph node metastasis of gastric carcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(03):1248.

备注/Memo

备注/Memo:
#通讯作者,男,1964年8月生,博士,教授,研究方向:肿瘤病理,Email:chenksh2002@yahoo.com.cn*河南省科技攻关计划基金资助项目092102310265
更新日期/Last Update: 2010-05-28