[1]赵先兰△,孙亚兰,张连琴.子痫前期患者胎盘组织中Endoglin、血管内皮生长因子及其跨膜型受体的表达[J].郑州大学学报(医学版),2010,(03):453-456.
 ZHAO Xianlan,SUN Yalan,ZHANG Lianqin.Expression of Endoglin,vascular endothelial growth factor and its fmslike tyrosine kinase receptor 1 in placental tissue of patients with preeclampsia[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):453-456.
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子痫前期患者胎盘组织中Endoglin、血管内皮生长因子及其跨膜型受体的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年03期
页码:
453-456
栏目:
论著
出版日期:
2010-05-15

文章信息/Info

Title:
Expression of Endoglin,vascular endothelial growth factor and its fmslike tyrosine kinase receptor 1 in placental tissue of patients with preeclampsia
作者:
赵先兰孙亚兰张连琴
郑州大学第一附属医院妇产科郑州450052
Author(s):
ZHAO Xianlan SUN Yalan ZHANG Lianqin
Department of Obstetrics and Gynecology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
子痫前期胎盘Endoglin血管内皮生长因子跨膜型血管内皮生长因子受体
Keywords:
preeclampsia placenta Endoglinvascular endothelial growth factorfmslike tyrosine kinase receptor 1
分类号:
R714.2
摘要:
检测子痫前期患者胎盘组织中Endoglin、血管内皮生长因子(VEGF)及其跨膜型受体(Flt1)的表达。方法:采用免疫组织化学SP法检测45例子痫前期患者(轻度子痫前期患者15例、重度30例)及同期足月妊娠分娩孕妇20例胎盘组织中Endoglin、VEGF及Flt1的表达。结果:对照组、轻度和重度子痫前期组胎盘组织中Endoglin的相对表达量分别为(86.88±6.80)、(99.45±6.88)和(118.88±6.13),3者相比,差异有统计学意义(F=69.683,P<0.001);VEGF的相对表达量分别为(133.70±6.08)、(117.57±6.44)和(104.60±4.98),3者相比,差异有统计学意义(F=68.877,P<0.001);Flt1的相对表达量分别为(129.00±5.76)、(142.30±4.55)和(154.32±5.16),3者相比,差异有统计学意义(F=66.555,P<0.001);随着病情的加重,胎盘组织Endoglin与Flt1蛋白的表达水平升高,VEGF的表达水平降低(P<0.05)。子痫前期患者胎盘组织中VEGF的表达与Flt1的表达呈负相关(r=-0.653,P=0.001)。结论:子痫前期患者胎盘组织中Endoglin与Flt1的高表达及VEGF的低表达可能参与了子痫前期的发病。
Abstract:
To investigate the expression of Endoglin,vascular endothelial growth factor (VEGF) and fmslike tyrosine kinase receptor 1(Flt1) in placenta of patients with preeclampsia(PE).

参考文献/References:

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备注/Memo

备注/Memo:
△女,1965年10月生,博士,教授,主任医师,研究方向:围产医学,Email:zxl12129@163.com
更新日期/Last Update: 2010-05-28