[1]郭长青)△,邵经浩),卢瑞利),等.胃癌组织中Beclin 1和PTEN蛋白的表达[J].郑州大学学报(医学版),2010,(03):463-465.
 GUO Changqing),SHAO Jinghao),LU Ruili),et al.Expression of Beclin 1 and PTEN proteins in gastric cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):463-465.
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胃癌组织中Beclin 1和PTEN蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年03期
页码:
463-465
栏目:
论著
出版日期:
2010-05-15

文章信息/Info

Title:
Expression of Beclin 1 and PTEN proteins in gastric cancer tissue
作者:
郭长青1)邵经浩1)卢瑞利1)曹新广2)
1)郑州大学第一附属医院消化内科郑州4500522)河南省肿瘤医院胃镜室郑州450003
Author(s):
GUO Changqing1)SHAO Jinghao1) LU Ruili1)CAO Xinguang2)
关键词:
胃癌 自噬Beclin 1PTEN
Keywords:
gastric cancerautophagyBeclin 1PTEN
分类号:
R735.2
摘要:
检测胃癌组织中自噬相关基因Beclin 1和PTEN蛋白的表达情况。方法:采用免疫组化SP法检测62例胃癌组织和36例正常胃组织中Beclin 1和PTEN蛋白的表达。结果:胃癌组织中Beclin 1和PTEN蛋白的阳性表达率分别为40.0%(25/62)和45.2%(28/62),均低于正常对照组的94.4%(34/36)和94.4%(34/36)(χ2分别为27.845、23.800,P均<0.001);胃癌组织分化程度越低,Beclin 1蛋白的阳性表达率越低(χ2=26.230,P<0.001);组织浸润深度越深、分化程度越低、伴淋巴结转移的胃癌组织PTEN阳性表达率越低(χ2=10.020、23.296和11.610,P均<0.001)。胃癌组织中Beclin 1和PTEN的表达呈正关联(rP=0.578,P<0.001)。结论:自噬活性的改变可能与胃癌的发生发展有关。
Abstract:
To investigate the expressions of autophagyrelated gene Beclin 1 and PTEN in gastric cancer tissue.Methods:Immunhistochemistry was used to detect the expressions of Beclin 1 and PTEN in 62 cases of gastric cancer and 36 cases of gastric normal tissue.

参考文献/References:

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备注/Memo

备注/Memo:
△男,1966年10月生,博士,教授,主任医师,研究方向:消化道肿瘤,Email:cqguo6610@hotmail.com
更新日期/Last Update: 2010-05-28