[1]林存侠),温洪涛)#,张蕾),等.胃癌组织中MTA1蛋白及微血管密度检测[J].郑州大学学报(医学版),2010,(03):466-468.
 LIN Cunxia),WEN Hongtao),ZHANG Lei),et al.Expression of MTA1 protein and MVD in gastric carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):466-468.
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胃癌组织中MTA1蛋白及微血管密度检测()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年03期
页码:
466-468
栏目:
论著
出版日期:
2010-05-15

文章信息/Info

Title:
Expression of MTA1 protein and MVD in gastric carcinoma tissue
作者:
林存侠1)温洪涛1)#张蕾2)张云汉3)
1)郑州大学第一附属医院消化内科郑州4500522)郑州大学第一附属医院肿瘤科郑州4500523)郑州大学第一附属医院病理科郑州450052
Author(s):
LIN Cunxia1)WEN Hongtao1)ZHANG Lei2) ZHANG Yunhan3)
关键词:
胃肿瘤MTA1微血管密度浸润转移
Keywords:
gastric neoplasmMTA1microvessel densityinvasionmetastasis
分类号:
R735.2
摘要:
研究正常胃黏膜及胃癌组织中MTA1蛋白和微血管密度(MVD)的表达情况及相互关系。方法:采用免疫组织化学法分别检测12例正常胃黏膜及63例胃癌组织中MTA1蛋白及MVD的表达情况。结果:正常胃黏膜及胃癌组织中MTA1蛋白阳性表达率分别为33.3%(4/12)和80.9%(51/63),差异有统计学意义(χ2=9.380,P=0.002);MVD值分别为(18.25±8.35)和(45.38±8.69),差异有统计学意义(t=9.974,P<0.001);胃癌组织中MTA1蛋白的表达与胃癌的浸润深度、分化程度及淋巴结转移有关(χ2分别为8.129、12.770和6.254,P均<0.05);MTA1蛋白表达者MVD值(47.49±7.69)高于MTA1蛋白未表达者(36.77±5.71)(t=5.265,P<0.001)。结论:MTA1蛋白过表达可能是胃癌浸润、转移和微血管生成的一个促进因素。
Abstract:
To explore the expression of MTA1 and microvessel density(MVD) and their relationships in gastric carcinoma tissue.Methods:The expressions of MTA1 and MVD were detected by immunohistochemistry in 12 cases of normal gastric mucosa tissues and 63 cases of gastric carcinoma tissues.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1968年2月生,博士,教授,主任医师,研究方向:消化道肿瘤的基础与临床,Email:wenhongtao68@163.com
更新日期/Last Update: 2010-05-28