[1]南燕,李红雨#,许雅娟.宫颈癌组织中TSPAN1与Ki67蛋白的表达[J].郑州大学学报(医学版),2010,(03):469-471.
 NAN Yan,LI Hongyu,XU Yajuan.Expression of TSPAN1 and Ki67 proteins in cervical carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):469-471.
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宫颈癌组织中TSPAN1与Ki67蛋白的表达 ()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年03期
页码:
469-471
栏目:
论著
出版日期:
2010-05-15

文章信息/Info

Title:
Expression of TSPAN1 and Ki67 proteins in cervical carcinoma tissue
作者:
南燕李红雨#许雅娟
郑州大学第三附属医院妇产科郑州450052
Author(s):
NAN YanLI HongyuXU Yajuan
关键词:
宫颈癌TSPAN1Ki67
Keywords:
cervical carcinomatetraspanin1Ki67
分类号:
R737.3
摘要:
探讨肿瘤相关蛋白TSPAN1与Ki67在宫颈癌组织中表达及其关联性。方法:应用免疫组织化学SP法检测正常宫颈、宫颈癌及宫颈内瘤样病变(CIN)组织(各30例)中TSPAN1及Ki67蛋白的表达。结果:正常宫颈、CIN和宫颈癌组织中TSPAN1和Ki67的阳性表达率分别为0(0/30)、36.7%(11/30)、73.3%(22/30)和13.3%(4/30)、53.3%(16/30)、80.0%(24/30),差异有统计学意义(χ2=34.737和27.036,P均<0.001),宫颈癌和CIN组织高于正常宫颈组织。宫颈癌组织中TSPAN1表达与淋巴结转移有关(P=0.014)。宫颈癌组织中TSPAN1与Ki67表达有关联性(χ2=8.960,rP=0.539,P<0.001)。结论:TSPAN1过表达与细胞增殖有关,参与宫颈癌的发生发展。
Abstract:
To study the expression levels of tetraspanin1(TSPAN1) and Ki67, and their relationship in cervical cancer.Methods:The expression levels of TSPAN1 and Ki67 proteins in normal cervix tissue,cervical cancer tissue and cervical intraepithelial neoplasia tissue (CIN) (each n=30) were detected by the immunohistochemical SP method.

参考文献/References:

[1]Serru V,Dessen P,Boucheix C,et al.Sequence and expression of seven new tetraspans[J]. Biochim Biophys Acta, 2000,1 478(1):159
[2]Jalava P,Kuopio T,JunttiPatinen L,et al. Ki67 immunohistochemistry:a valuable marker in prognostication but with a risk of misclassifi cation:proliferation subgroups formed based on Ki67 immunoreactivity and standardized mitotic index[J].Histopathology,2006,48(6):674
[3]Chen L,Wang ZW,Zhen X,et al.Association of NET1 gene expression with human hepatocellular carcinoma[J].Int J Surg Pathol,2007,15(4):346
[4]Gerdes J,Lemke H,Baxsch H,et al.Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibooly Ki67[J].J Immunol,1984,133(4):1 710
[5]Wollscheid V,KuhneHeid R,Stein I,et al.Identification of a new proliferationassociated protein NET1/C4.8 characteristic for a subset of highgrade cervical intraepithelial neoplasia and cervical carcinoma[J]. Int J Cancer,2002,99(6):771
[6]Chen L, Wang Z, Zhen X, et al. Association of NET1 gene expression with human hepatocellular carcinoma[J].Int J Surg Pathol,2007,15(4):346
[7]钱铮,陈莉,王桂兰,等.胃癌NET1、Ki67表达及意义[J].临床与实验病理学杂志,2008,24(3):305
[8]李杏玉,陈莉.NET1和MIB1在肝癌中的表达及意义[J].天津医药,2009,37(11):917

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备注/Memo

备注/Memo:
#通讯作者,女,1964年5月生,博士,教授,研究方向:妇科肿瘤;Email:tjhylucky@yahoo.com.cn
更新日期/Last Update: 2010-05-28