[1]齐宇)△,李鑫),杨鲲鹏),等.支气管肺泡灌洗液中CYFRA211、NSE和CEA联合检测对肺癌的诊断价值[J].郑州大学学报(医学版),2010,(04):618.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):618.
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支气管肺泡灌洗液中CYFRA211、NSE和CEA联合检测对肺癌的诊断价值()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年04期
页码:
618
栏目:
论著
出版日期:
2010-07-30

文章信息/Info

作者:
齐宇1)△李鑫2)杨鲲鹏3)袁天柱3)袁前超4)寿化山3)
1)郑州大学第一附属医院胸外科 郑州450052
2)郑州大学第一附属医院肿瘤科 郑州 450052
3)郑州大学第二附属医院胸外科  郑州 450014
4)三门峡市人民医院外科 三门峡 472000
关键词:
肺癌支气管肺泡灌洗液可溶性细胞角蛋白19片段神经元特异性烯醇化酶癌胚抗原
文献标志码:
A
摘要:
目的:探讨支气管肺泡灌洗液(BALF)中可溶性细胞角蛋白19片段(CYFRA211)、神经元特异性烯醇化酶(NSE)和癌胚抗原(CEA)联合检测对肺癌的诊断价值。方法:肺癌患者45例和肺良性病变患者20例(对照组),按照纤维支气管镜操作技术常规取2组对象的BALF,采用免疫放射法检测CYFRA211、NSE的水平,采用放射免疫法检测CEA的水平。绘制BALF中CYFRA211、NSE和CEA 3种标志物的受试者工作特征曲线(ROC),确定临界值,以≥临界值为阳性,计算敏感度、特异度及约登指数。结果:肺癌组BALF中CYFRA211、NSE和CEA的最佳临界点值分别为为36.25、7.87和25.91 μg/L。3者联合检测串联试验的约登指数为51.7%,高于非联合检测时各单项指标的约登指数(CYFRA211为32.1%,NSE为30.0%,CEA为25.6%)。联合检测并联试验的约登指数为40%,但特异度可达100%。结论:BALF中CYFRA211、NSE及CEA联合检测可提高肺癌诊断率,降低漏诊率。

参考文献/References:

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