[1]马杰,张秋堂,刘林湘,等.成人急性T淋巴细胞白血病患者髓系抗原的表达[J].郑州大学学报(医学版),2010,(04):623.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):623.
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成人急性T淋巴细胞白血病患者髓系抗原的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年04期
页码:
623
栏目:
论著
出版日期:
2010-07-30

文章信息/Info

作者:
马杰张秋堂刘林湘孙慧李涛刘延方陈绍倩孙玲
郑州大学第一附属医院血液科;河南省高等学校临床医学重点学科开放实验室 郑州  450052
关键词:
成人急性T淋巴细胞白血病髓系抗原临床特征
文献标志码:
A
摘要:
目的:观察成人急性T淋巴细胞白血病(TALL)患者中髓系抗原(MyAg)的表达及意义。方法:采用CD45/SSC参数设门多色流式细胞术检测63例成人TALL患者骨髓细胞的免疫表型,分析MyAg+ TALL患者的临床特征。结果:①49.2%的成人TALL患者表达MyAg,以CD13(33.3%)和CD33(25.4%)为主,CD117和CD64阳性率分别为12.7%和3.2%,未检测到CD14表达。②MyAg+TALL患者高白细胞性白血病和肝脾浸润发生率及CD2的表达均低于MyAg- TALL患者(χ2分别为6.232,5.769和4.872,P均<0.05),2组诱导死亡率(3/22 vs 3/29)及完全缓解率(14/19 vs 23/26)差异无统计学意义(χ2分别为0.006,1.640,P均>0.05)。MyAg单一表达或联合表达对成人TALL患者的临床特征无影响。结论:MyAg的表达在成人TALL中并不少见;MyAg表达与高白细胞性白血病、肝脾浸润、CD2表达有关,与诱导治疗反应无关。

参考文献/References:

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