[1]李瓅,曾昭书,周艳梅,等.第10号染色体一个祖先信息标记区域的发现及鉴定[J].郑州大学学报(医学版),2010,(05):740-745.
 LI Li),ZENG Zhaoshu),ZHOU Yanmei),et al.Finding and confirmation of an ancestor informative marker region on chromosome 10[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(05):740-745.
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第10号染色体一个祖先信息标记区域的发现及鉴定
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年05期
页码:
740-745
栏目:
论著
出版日期:
2010-09-30

文章信息/Info

Title:
Finding and confirmation of an ancestor informative marker region on chromosome 10
作者:
李瓅1曾昭书2周艳梅1董子明3
1)郑州市中心医院妇产科 郑州 450007
2)郑州大学基础医学院法医学教研室 郑州 450001
3)郑州大学基础医学院病理生理学教研室 郑州 450001
Author(s):
LI Li1)ZENG Zhaoshu2)ZHOU Yanmei1)DONG Ziming3)
1)Department of Obstetrics and Genecology,Zhengzhou Central Hospital,Zhengzhou 4500072)Department of Forensic Medicine,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 4500013)Department of Pathology and Physiology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001
关键词:
祖先信息标记单核苷酸多态性固定系数HapMap
分类号:
R394.5
摘要:
目的:应用第10号染色体的HapMap单核苷酸多态性(SNP)基因分型数据及人群聚类分析技术区分人亚群。方法:从HapMap数据库(r23)获取北京汉族人、欧裔和非裔3个人群225个样本的第10号染色体共4 660余万个SNPs分型结果,提取在3个群体间等位基因频率差值大于0.3的SNPs,以Genepop 4.0软件计算固定系数(Fst),以Structure 2.3软件进行聚类分析。结果:在3个群体间得到等位基因频率差值大于0.3的SNPs共2 910个,位于该染色体长臂末端118 000 000 bp处的rs10510019、rs10787669、rs713252与rs919613的Fst均大于0.660,平均Fst为0.674,该4个SNPs处于强连锁不平衡状态,形成一个跨度为13 455 bp的区域。结论:包含4个SNPs的祖先信息标记区域的发现,可以有效提示某个人是否归属于欧裔、非裔或北京汉族人群,并为组建复合PCR体系提供了备选SNPs。

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备注/Memo

备注/Memo:
国家自然科学基金资助项目30700966;31071100
更新日期/Last Update: 2010-10-28