[1]王威,郝长付,吴拥军#,等.p53 Arg/Pro基因多态性及吸烟对河南汉族人群肺癌发病的影响[J].郑州大学学报(医学版),2010,(05):746-748.
 WANG Wei,HAO Changfu,WU Yongjun,et al.Effects of p53 Arg/Pro gene polymorphism and smoking on the occurrence of lung cancer in Henan Han population[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(05):746-748.
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p53 Arg/Pro基因多态性及吸烟对河南汉族人群肺癌发病的影响
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2010年05期
页码:
746-748
栏目:
论著
出版日期:
2010-09-30

文章信息/Info

Title:
Effects of p53 Arg/Pro gene polymorphism and smoking on the occurrence of lung cancer in Henan Han population
作者:
王威郝长付吴拥军#吴逸明
郑州大学公共卫生学院劳动卫生与职业病学教研室 郑州 450001
Author(s):
WANG WeiHAO ChangfuWU YongjunWU Yiming
Department of Occupational Health,College of Public Health, Zhengzhou University, Zhengzhou 450001
关键词:
p53肺肿瘤吸烟基因多态性河南汉族
分类号:
R734.2
摘要:
目的:检测p53基因第4外显子的第72密码子Arg/Pro多态性及吸烟对河南汉族人肺癌发病的影响。方法:采用PCR限制性片段长度多态性技术检测124例肺癌患者和128名对照(病例和对照均为河南汉族人)p53基因Arg/Pro多态性,同时调查两组人群的吸烟状况,比较基因多态性和吸烟在两组中的分布情况。结果:对照组和肺癌组人群Pro/Pro 基因型频率分别为15.6%和28.2%,与携带Arg/Arg和Arg/Pro基因型者比较,携带Pro/Pro基因型个体患肺癌危险增加且其调整OR(95%CI) 为2.11(1.12~3.97)。以不吸烟和非Pro/Pro基因型者为参照,Pro/Pro基因型和吸烟单独作用的调整OR(95%CI)分别为0.93(0.36~2.38)和2.27(1.13~4.54),二因素共同存在时的调整OR(95%CI)为10.49(3.42~32.23), Pro/Pro基因型与吸烟存在交互作用(χ2=5.209,P=0.023)。结论:吸烟、p53 Pro/Pro基因型及其二者交互作用可能是河南汉族人群肺癌发病的危险因素。

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更新日期/Last Update: 2010-10-28