[1]朱宇皇,高艳锋,吕虹,等.结核分枝杆菌抗原Rv1258c、Rv1410c及Rv3425的HLA限制性CTL表位预测[J].郑州大学学报(医学版),2011,(01):13.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(01):13.
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结核分枝杆菌抗原Rv1258c、Rv1410c及Rv3425的HLA限制性CTL表位预测()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年01期
页码:
13
栏目:
论著
出版日期:
2011-01-20

文章信息/Info

作者:
朱宇皇高艳锋吕虹祁元明
郑州大学生物工程系 郑州 450001
关键词:
结核分枝杆菌Rv1258cRv3425Rv1410c
文献标志码:
A
摘要:
目的:预测结核分枝杆菌(MTB)相关抗原Rv1258c、Rv1410c及Rv3425的HLA限制性细胞毒性T细胞(CTL)表位。方法:通过NCBI数据库获取各蛋白的氨基酸序列,利用BLAST分析其与人类蛋白质的同源性,利用SYFPEITHI、BIMAS和NetCTL数据库预测分析MTB相关抗原的HLAA2与HLAA3限制性CTL表位。结果:初步筛选出3个候选抗原的HLAA2和HLAA3限制性CTL优势表位,分别为Rv1258c 343~351、380~388、290~298、52~60;Rv1410c 510~518、470~478、452~460、420~428;Rv3425 118~126、43~51、29~37。结论:预测出MTB 3个相关抗原的HLAA2与HLAA3限制性CTL表位,为抗结核多表位疫苗的研究奠定了基础。

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