[1]刘桂举,梅家转,肖鹏,等.化疗联合细胞因子诱导的杀伤细胞治疗晚期食管癌的疗效[J].郑州大学学报(医学版),2011,(02):169.
 LIU Guiju,MEI Jiazhuan,XIAO Peng,et al.Efficacy of chemotherapy combined with cytokineinduced killer cells in treatment of advanced esophageal carcinoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):169.
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化疗联合细胞因子诱导的杀伤细胞治疗晚期食管癌的疗效()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年02期
页码:
169
栏目:
食管癌研究
出版日期:
2011-03-20

文章信息/Info

Title:
Efficacy of chemotherapy combined with cytokineinduced killer cells in treatment of advanced esophageal carcinoma
作者:
刘桂举梅家转肖鹏李瑞君栗敏
郑州人民医院肿瘤内科 郑州 450003
Author(s):
LIU GuijuMEI JiazhuanXIAO PengLI RuijunLI Min
Department of Oncology, Zhengzhou People’s Hospital, Zhengzhou 450003
关键词:
细胞因子诱导的杀伤细胞食管肿瘤化疗
分类号:
R735.1
文献标志码:
A
摘要:
目的:评价化疗联合细胞因子诱导的杀伤细胞(CIK)治疗晚期食管癌的疗效。方法:40例非手术治疗的晚期食管癌患者分2组化疗,每组20例。单纯化疗组:顺铂(25 mg/m2,静脉滴注,第1~3天)、四氢叶酸钙(100 mg,静脉滴注,第1~5天)和5GAAB2氟尿嘧啶(500 mg/m2,静脉滴注,第1~5天),每3周1次,每2个周期评价疗效,进展患者改为紫杉醇(135 mg/m2,静脉滴注,第1天)和顺铂(25 mg/m2,静脉滴注,第1~3天),每3周1次。最多化疗6个周期。联合治疗组:化疗方案同上,在每周期化疗间歇期回输CIK 6~8次。观察2组患者近期疗效、生活质量、外周血淋巴细胞表型及生存率。〖HTH〗结果〖HTSS〗:联合治疗组和单纯化疗组近期疗效有效率均为35%,疾病控制率分别为65%和50%,差异均无统计学意义(χ分别为<0.001和0.921,P均>0.05);肿瘤进展时间分别为(8.9±1.1)和(6.7±0.7)个月(t=7.295,P<0.001);1 a生存率分别为75%、40%(χ=5.013,P=0.025)。联合治疗组患者外周血CD3+、CD4+、CD4+CD8+、CD3+CD56+细胞的比例及KPS评分较治疗前升高(t分别为11.344、13.056、3.891、16.844及3.025,P<0.05),单纯化疗组无明显变化(P>0.05)。结论:化疗联合CIK治疗晚期食管癌较单纯化疗有潜在的优势。

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备注/Memo

备注/Memo:
*郑州市科技计划攻关基金资助项目200911;郑州市博士创业基金资助项目2009175
#通讯作者,男,1966年2月生,博士,主任医师,研究方向:肿瘤生物治疗,E-mail:mjzhuan@163.com
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