[1]芦红,吴月霞,杨丽嘉,等. 川佛手提取物对小鼠的抗抑郁作用*[J].郑州大学学报(医学版),2011,(02):220.
 LU Hong,WU Yuexia,YANG Lijia,et al. Antidepressant effects of Citrus medica L. var. sarcodactylis swingle from Sichuan province[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):220.
点击复制

 川佛手提取物对小鼠的抗抑郁作用*()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年02期
页码:
220
栏目:
论著
出版日期:
2011-03-20

文章信息/Info

Title:
 Antidepressant effects of Citrus medica L. var. sarcodactylis swingle from Sichuan province
作者:
 芦红吴月霞杨丽嘉李继成#张伟刘娜
 郑州大学药学院 郑州450001
Author(s):
 LU HongWU YuexiaYANG LijiaLI JichengZHANG Wei LIU Na
 College of Pharmacy, Zhengzhou University,Zhengzhou 450001
关键词:
 郑州大学药学院 郑州450001
分类号:
R284.1
文献标志码:
A
摘要:
 目的:研究川佛手提取物的抗抑郁作用。方法:采用水蒸气蒸馏法制备川佛手挥发油,采用回流提取法制备川佛手水提浸膏Ⅰ、川佛手水提后醇提浸膏Ⅱ和Ⅲ、石油醚浸膏、乙酸乙酯浸膏和正丁醇浸膏,以生理盐水为空白对照,氟西汀为阳性对照药,采用小鼠强迫游泳实验和小鼠悬尾实验测定上述提取物实验4 min内对小鼠游泳和悬尾的不动时间的影响。结果:与空白对照组 [(142.30±9.97) s] 相比,阳性对照药氟西汀组、川佛手挥发油组、浸膏Ⅱ组、浸膏Ⅲ组小鼠游泳时不动时间均缩短[(80.80±6.33)、(77.20±10.73)、(107.40±12.28)和(78.30±9.33) s,F=11.080,P<0.001],而浸膏Ⅰ组[(141.30±6.09) s]效果不明显。与空白对照组[(115.60±6.44) s]相比,氟西汀组、正丁醇浸膏组小鼠悬尾不动时间均缩短[(82.50±4.54)和(91.00±8.04) s,F=5.548,P=0.015]。结论:川佛手具有一定的抗抑郁作用。

参考文献/References:

 [1]崔红花,高幼衡,梁盛林,等.川佛手化学成分研究:Ⅰ[J].中草药,2007,38(9):344
[2]Sakurada T, Kuwahata H, Katsuyama S, et al. Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicininduced nociceptive behaviors[J]. Int Rev Neurobiol,2009,85:237
[3]Corasaniti MT,Maiuolo J, Maida S, et al.Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDAinduced cell death in vitro[J].Br J Phamacol,2007,151(4):518
[4]Sanguinetti M,Posteraro B,Romano L,et al.In vitro activity of Citrus bergamia(bergamot) oil against clinical isolates of dermatophytes[J].J Antimicrob Chemother,2007,59(2):305
[5]李继成,杨丽嘉,付春景,等.消郁宁的抗抑郁作用[J].中草药,2005,36(增刊):175
[6]Sarris J,Kavanagh DJ,Byrne G. Adjuvant use of nutritional and herbal medicines with antidepressants, mood stabilizers and benzodiazepines[J]. J Psychiatr Res,2010,44(1):32
[7]杜书章,岳晓红,张晓坚,等. 噻奈普汀治疗老年抑郁症43例[J]. 郑州大学学报:医学版,2008,43(2):377
[8]杨杨,高成阁,于学文. 5HTTLPR多态性与抑郁症及其临床特征的相关性[J]. 西安交通大学学报:医学版,2007,28(1):18
[9]Sarris J.Herbal medicines in the treatment of psychiatric disorders: a systematic review[J].Phytother Res,2007,21(8):703

相似文献/References:

[1]杨海燕),冯若),范秋萍)#,等. 基层医疗机构医院感染预防与消毒灭菌培训效果评价*[J].郑州大学学报(医学版),2009,(02):346.
 YANG Haiyan ),FENG Ruo),FAN Qiuping),et al. Analysis on effects of training disinfection and isolation knowledge to basic medicical staff[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(02):346.
[2]马望,樊青霞,王留兴#,等.非小细胞肺癌患者化疗前后血清IGF1和IGFBP3水平的变化[J].郑州大学学报(医学版),2010,(04):663.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):663.
[3]曾利,徐慧,张傅山.河南省某医院鲍曼不动杆菌的临床分布及耐药性观察[J].郑州大学学报(医学版),2010,(04):664.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):664.
[4]周文科),张新中),周国胜),等.前循环动脉瘤336例显微手术体会[J].郑州大学学报(医学版),2011,(01):112.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):112.
[5]钟志超,范洪领,尹金宝,等.氯通道电流在离体大鼠海马缺血缺氧性神经元凋亡中的变化及SITS的拮抗作用*[J].郑州大学学报(医学版),2011,(03):367.
 ZHONG Zhichao,FAN Hongling,YIN Jinbao,et al. Changes of chloride channel currents during cultured rat hippocampal neuronal apoptosis and antieffects of SITS[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):367.
[6]葛辰蕾),李醒亚),尚可),等.非小细胞肺癌预后影响因素分析*[J].郑州大学学报(医学版),2011,(02):216.
 GE Chenlei),LI Xingya),SHANG Ke),et al. Analysis of prognostic factors for nonsmall cell lung cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):216.
[7]黄月),张善锋),许予明)#,等. 6羟基多巴胺诱导帕金森病大鼠相关蛋白及mRNA的表达[J].郑州大学学报(医学版),2011,(02):222.
 HUAGN Yue,ZHANG Shanfeng,et al. Expression of related protein and mRNA in 6hydroxydopamineinduced Parkinson’s disease rats[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):222.
[8]宋丽君),刘建新),陈辉),等. 河南汉族人群9个Y染色体短串联重复序列单倍型遗传多态性[J].郑州大学学报(医学版),2011,(02):225.
 SONG Lijun),LIU Jianxin),CHEN Hui),et al. Haplotype genetic polymorphism of 9 YSTR in Henan Han population[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):225.
[9]赵倩△,边爱平,王春芳. 子宫内膜异位症患者内膜组织中Livin和Smac蛋白的表达[J].郑州大学学报(医学版),2011,(02):228.
 ZHAO Qian,BIAN Aiping,WANG Chunfang. Expression of Livin and Smac protein in endometrium of endometriosis patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):228.
[10]杨玲竹△,李亚敏. 子痫前期患者胎盘组织中晚期糖基化终产物受体和P选择素的表达[J].郑州大学学报(医学版),2011,(02):231.
 YANG Lingzhu,LI Yamin. Expression of receptor of advanced glycation end products and Pselectin in placenta of preeclampsia patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):231.

备注/Memo

备注/Memo:
 #通讯作者,男,1953年7月生,本科,教授,研究方向:新药的研究和开发,E-mail:Lijicheng@zzu.edu.cn
*河南省基础与前沿技术研究计划基金资助项目0411044700
更新日期/Last Update: