[1]杨玲竹△,李亚敏. 子痫前期患者胎盘组织中晚期糖基化终产物受体和P选择素的表达[J].郑州大学学报(医学版),2011,(02):231.
 YANG Lingzhu,LI Yamin. Expression of receptor of advanced glycation end products and Pselectin in placenta of preeclampsia patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):231.
点击复制

 子痫前期患者胎盘组织中晚期糖基化终产物受体和P选择素的表达()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年02期
页码:
231
栏目:
论著
出版日期:
2011-03-20

文章信息/Info

Title:
 Expression of receptor of advanced glycation end products and Pselectin in placenta of preeclampsia patients
作者:
 杨玲竹△李亚敏
 郑州大学第一附属医院妇产科 郑州 450052
Author(s):
 YANG Lingzhu LI Yamin
 Department of Obstetrics and Gynecology, the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
 晚期糖基化终产物受体P选择素子痫前期
分类号:
R714.25
文献标志码:
A
摘要:
 目的:探讨晚期糖基化终产物受体(RAGE)和P选择素(Pselectin)在子痫前期(PE)发生发展中的作用。方法:采用免疫组织化学SP法和RTPCR法检测30例正常孕妇(对照组)和40例PE患者(轻度20例、重度20例)胎盘组织中RAGE 和Pselectin蛋白及mRNA的表达情况。结果:对照组与PE组胎盘组织内均有RAGE和Pselectin阳性表达,RAGE主要表达于滋养细胞,血管内皮细胞中也有少量表达;Pselectin主要表达于合体滋养细胞、血管内皮细胞及间质细胞。3组RAGE和Pselectin蛋白(F=250.152和274.044,P均<0.001)及mRNA(F=624.550和708.351,P均<0.001)比较,差异均有统计学意义。轻、重度PE组RAGE、Pselectin蛋白和mRNA表达高于对照组(P均<0.05),重度PE组高于轻度PE组(P均<0.05);PE患者胎盘组织中2种蛋白及mRNA表达均呈正相关(r=0.814和0.796,P均<0.001)。结论:RAGE和Pselectin表达升高可能与PE的发生发展有关,二者在PE的发病中有协同作用。

参考文献/References:

 [1]Lei F, Carolyn M, Allan S, et al. Chronic vascular inflammation in patients with type 2 diabetes[J].Diabetes Care,2005,28(2):379
[2]Konishi H, Nakatsuka M, Chekir C, et al. Advanced glycation end products induce secretion of chemokines and apoptosis in human first trimester trophoblasts[J].Hum Reprod,2004,19(9):2156
[3]乐杰.妇产科学[M].7版. 北京:人民卫生出版社,2008:92
[4]Schmidt AM, Hori O, Chen JX, et al. RAGE a novel receptor for AGEs[J].Diabetes,1996,45(Suppl 3):s77
[5]Toth C,Rong LI,Yang C,et al.Receptor for ad vanced glycation end products(RAGEs) and experimental diabetic neuropathy[J].Diabetes,2008,57(4):1002
[6]郑建杰,马爱群,王宏雁.Ⅰ型胶原及NF κB与动脉粥样硬化关系的实验研究[J].西安交通大学学报:医学版,2005,26(5):441
[7]赵毅,于铁成,金安.p38 MAPK对冲击波促进T淋巴细胞增殖和分泌 IL2 的作用[J].吉林大学学报:医学版,2007,33(5):815
[8]Chekir C,Nakatsuka M,Noguchi S,et al.Accumulation of advanced glycation end products in women with preeclampsia:possible involvement of placental oxidative and nitrative stress[J].Placenta, 2006, 27(2/3):225
[9]Schulz C,Schafer A,Stolla M,et al.Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood:a critical role for Pselectin expressed on activated platelets[J].Circulation,2007,116(7):764
[10]Uszynski M,Uszynski W,Zekanowska E,et al.Pselectin in placenta and gestational myometrium: its measurements and hypothetical role in hemostasis of placental bed after labor[J].J Perinat Med,2008,36(3):213
[11]爱勇,赵玉武.晚期糖基化终产物及其受体与糖尿病相关神经系统疾病[J].中国神经免疫学和神经病学杂志,2009,16(2):411
[12]Bierhaus A,Schiekofer S,Schwaninger M,et al.Diabetesassociated sustatined activation of the transcription factor nuclear factorkappaB[J].Diabetes,2001,50(12):2792
[13]Meager A.Cytokine regulation of cellular adhesion molecule expression in inflammation [J].Cytokine Growth Factor Rev,1999,10(1):27

相似文献/References:

[1]杨海燕),冯若),范秋萍)#,等. 基层医疗机构医院感染预防与消毒灭菌培训效果评价*[J].郑州大学学报(医学版),2009,(02):346.
 YANG Haiyan ),FENG Ruo),FAN Qiuping),et al. Analysis on effects of training disinfection and isolation knowledge to basic medicical staff[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(02):346.
[2]马望,樊青霞,王留兴#,等.非小细胞肺癌患者化疗前后血清IGF1和IGFBP3水平的变化[J].郑州大学学报(医学版),2010,(04):663.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):663.
[3]曾利,徐慧,张傅山.河南省某医院鲍曼不动杆菌的临床分布及耐药性观察[J].郑州大学学报(医学版),2010,(04):664.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(02):664.
[4]周文科),张新中),周国胜),等.前循环动脉瘤336例显微手术体会[J].郑州大学学报(医学版),2011,(01):112.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):112.
[5]钟志超,范洪领,尹金宝,等.氯通道电流在离体大鼠海马缺血缺氧性神经元凋亡中的变化及SITS的拮抗作用*[J].郑州大学学报(医学版),2011,(03):367.
 ZHONG Zhichao,FAN Hongling,YIN Jinbao,et al. Changes of chloride channel currents during cultured rat hippocampal neuronal apoptosis and antieffects of SITS[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):367.
[6]葛辰蕾),李醒亚),尚可),等.非小细胞肺癌预后影响因素分析*[J].郑州大学学报(医学版),2011,(02):216.
 GE Chenlei),LI Xingya),SHANG Ke),et al. Analysis of prognostic factors for nonsmall cell lung cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):216.
[7]芦红,吴月霞,杨丽嘉,等. 川佛手提取物对小鼠的抗抑郁作用*[J].郑州大学学报(医学版),2011,(02):220.
 LU Hong,WU Yuexia,YANG Lijia,et al. Antidepressant effects of Citrus medica L. var. sarcodactylis swingle from Sichuan province[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):220.
[8]黄月),张善锋),许予明)#,等. 6羟基多巴胺诱导帕金森病大鼠相关蛋白及mRNA的表达[J].郑州大学学报(医学版),2011,(02):222.
 HUAGN Yue,ZHANG Shanfeng,et al. Expression of related protein and mRNA in 6hydroxydopamineinduced Parkinson’s disease rats[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):222.
[9]宋丽君),刘建新),陈辉),等. 河南汉族人群9个Y染色体短串联重复序列单倍型遗传多态性[J].郑州大学学报(医学版),2011,(02):225.
 SONG Lijun),LIU Jianxin),CHEN Hui),et al. Haplotype genetic polymorphism of 9 YSTR in Henan Han population[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):225.
[10]赵倩△,边爱平,王春芳. 子宫内膜异位症患者内膜组织中Livin和Smac蛋白的表达[J].郑州大学学报(医学版),2011,(02):228.
 ZHAO Qian,BIAN Aiping,WANG Chunfang. Expression of Livin and Smac protein in endometrium of endometriosis patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):228.

备注/Memo

备注/Memo:
 △女,1956年5月生,硕士,教授,研究方向:围产医学
更新日期/Last Update: