[1]翟军),孙莹璞)#. 二甲双胍对PCOS患者血清TNFα水平及内分泌代谢的影响[J].郑州大学学报(医学版),2011,(02):235.
 ZHAI Jun),SUN Yingpu). Effect of metformin on serum TNFα levels,endocrine and metabolic festures of PCOS patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(02):235.
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 二甲双胍对PCOS患者血清TNFα水平及内分泌代谢的影响()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年02期
页码:
235
栏目:
论著
出版日期:
2011-03-20

文章信息/Info

Title:
 Effect of metformin on serum TNFα levels,endocrine and metabolic festures of PCOS patients
作者:
 翟军12)孙莹璞1)#
 1)郑州大学第一附属医院生殖中心 郑州 4500522)郑州人民医院妇产科 郑州 450003
Author(s):
 ZHAI Jun12)SUN Yingpu1)
 1)Reproductive Medical Center,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
2)Department of Obstetrics and Gynecology,Zhengzhou People’s Hospital,Zhengzhou 450003
关键词:
 多囊卵巢综合征二甲双胍肿瘤坏死因子α肥胖
分类号:
R711.75
文献标志码:
A
摘要:
 目的:探讨二甲双胍对多囊卵巢综合征(PCOS)患者血清肿瘤坏死因子α(TNFα)水平及内分泌代谢的影响。方法:对24例肥胖型和20例非肥胖型PCOS患者应用二甲双胍(500 mg/次,3次/d,连续3个月)进行治疗。分析治疗前后2组临床症状、血清TNFα水平及内分泌代谢的改变。结果:肥胖型患者体质指数(BMI)、血清TNFα水平、空腹胰岛素(FINS)、胰岛素曲线下面积(AUCI)及血雌激素(E2)、雄激素(T)水平均高于非肥胖型患者(P<0.05),而非肥胖型患者胰岛素敏感指数(ISI)、促黄体生成素(LH)高于肥胖型患者(P<0.05) 。二甲双胍治疗后, 2组患者血清TNFα、LH、E2、T、FINS及AUCI水平下降(P<0.05),ISI升高(P<0.05)。2组患者临床症状均得到了改善,肥胖型和非肥胖型患者自主排卵率差异无统计学意义(43.5% vs 63.2%,χ2=1.616,P=0.204),2组治疗过程中各有2例妊娠。PCOS患者血清TNFα水平与BMI呈正相关(r=0.485,P=0.002),与ISI呈负相关(r=-0.437,P=0.004)。结论:二甲双胍可降低PCOS患者血清TNFα、LH及T水平,提高胰岛素敏感性,对肥胖及非肥胖型患者均有效,尤其适用于肥胖型患者。

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备注/Memo

备注/Memo:
 #通讯作者,女,1962年1月生,博士,教授,研究方向:生殖医学基础与临床,Email:syp2008@vip.sina.com
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