[1]李晓丽△,林锐,李建生,等.胃腺癌组织中核转录因子κBP65蛋白的表达[J].郑州大学学报(医学版),2011,(04):575.
 LI Xiaoli,LIN Rui,LI Jiansheng,et al.Expression of nuclear factorκBP65 protein in gastric carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(04):575.
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胃腺癌组织中核转录因子κBP65蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年04期
页码:
575
栏目:
论著
出版日期:
2011-07-15

文章信息/Info

Title:
Expression of nuclear factorκBP65 protein in gastric carcinoma tissue
作者:
李晓丽1林锐2李建生2李继昌2
1)郑州大学第一附属医院老年病科;河南省高等学校临床医学重点学科开放实验室 郑州 4500522)郑州大学第一附属医院消化内科 郑州 450052
Author(s):
LI Xiaoli1) LIN Rui2)LI Jiansheng2) LI Jichang2)
1)Department of Geriatrics, the First Affilicated Hospital, Zhengzhou University; Open Laboratory of Key Science of Clinical Medicine of Henan Province, Zhengzhou 4500522)Department of Gastroenterology, the First Affilicated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
胃癌胃不典型增生核转录因子κBP65
Keywords:
gastric carcinoma gastric dysplasia nuclear factorκBP65
分类号:
R735.2
摘要:
目的:检测胃癌、癌前病变及正常胃黏膜组织中核转录因子κBP65(NFκBP65)蛋白的表达情况,探讨其与胃癌发生发展的关系。方法:采用免疫组织化学法对20例正常胃黏膜、32例胃不典型增生及63例胃癌组织中的核转录因子κBP65蛋白表达进行检测。结果:NFκBP65蛋白在胃癌组织中的阳性率表达率(74.6%, 47/63)与胃不典型增生组织(46.9%,15/32)及正常胃黏膜组织(5.0%,1/20)相比,差异有统计学意义(χ2=34.795,P<0.001)。胃癌组织中,NFκBP65蛋白的阳性表达率与分化程度、浸润深度及有无淋巴结转移有关(χ2分别为6.426、6.682和5.416,P均<0.05)。结论:NFκBP65不仅与胃癌的形成有关,且与胃癌的侵袭和转移有关。
Abstract:
Aim:To investigate the expression of nuclear factorκBP65 (NFκBP65) protein in human gastric carcinoma tissue, precarcinoma changes, and normal gastric mucous tissue.Methods:NFκBP65 protein were detected in 20 cases of normal gastric mucous, 32 cases of gastric dysplasia and 63 cases of gastric carcinoma tissue specimens using immunohistochemistry.Results:There was significant difference on positive expression rate of NFκBP65 protein among gastric carcinoma(74.6%, 47/63), gastric dysplasia(46.9%,15/32) and normal gastric mucous(5.0%,1/20) tissues(χ2=34.795,P<0.001).The expression of NFκBP65 protein in gastric carcinoma tissue was associated with histological grade, invasive depth and lymph node metastasis (χ2=6.426,6.682,and 5.416,P<0.05).Conclusion: NFκBP65 might be correlated with occurrence, invasion and metastasis of gastric carcinoma.

参考文献/References:

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备注/Memo

备注/Memo:
△女,1977年2月生,硕士,主治医师,研究方向:消化道肿瘤:Email:lxl039921@sina.com
更新日期/Last Update: 1900-01-01