[1]陆晓青,刘章锁#,申万琴,等.成人膜性乙肝病毒相关性肾炎与特发性膜性肾病临床病理特征比较[J].郑州大学学报(医学版),2011,(04):601.
 LU Xiaoqing,LIU Zhangsuo,SHEN Wanqin,et al.Comparison of clinical and pathological features between HBVassociated membranous nephropathy and idiopathic membranous nephropathy in adults[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(04):601.
点击复制

成人膜性乙肝病毒相关性肾炎与特发性膜性肾病临床病理特征比较
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年04期
页码:
601
栏目:
论著
出版日期:
2011-07-15

文章信息/Info

Title:
Comparison of clinical and pathological features between HBVassociated membranous nephropathy and idiopathic membranous nephropathy in adults
作者:
陆晓青刘章锁#申万琴王源春
郑州大学第一附属医院肾内科 郑州 450052
Author(s):
LU XiaoqingLIU ZhangsuoSHEN WanqinWANG Yuanchun
Department of Nephrology, the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
膜性乙肝病毒相关性肾炎特发性膜性肾病成人临床特点病理特点
Keywords:
HBVassociated membranous nephropathyidiopathic membranous nephropathyadultclinical featurepathological feature
分类号:
R692.5
摘要:
目的:探讨成人膜性乙肝病毒相关性肾炎(HBVMN)与特发性膜性肾病(IMN)临床病理特征之间的异同。方法:回顾性分析HBVMN(70例)与IMV(137例)患者的临床病理资料,分析比较2组的临床病理特征。结果:HBVMN发病年龄小于IMN[(31.7±14.0)岁 vs(47.1±13.0)岁;t=3.533,P<0.001];病理上HBVMN伴发系膜增生较IMN更常见(98.6% vs 69.3%;χ2=24.048,P<0.001),HBVMN多为多种免疫复合物沉积,2组IgM、IgA、C3、C1q(χ2=18.175、21.990、16.448和50.846,P均<0.001)、FRA(P=0.007)在肾组织的沉积率差异均有统计学意义。结论:HBVMN与IMN临床特征相似,病理改变存在一定差别,诊断需要临床与病理相结合综合分析。
Abstract:
Aim: To investigate the clinical and pathological differences between HBVassociated membranous nephropathy(HBVMN) and idiopathic membranous nephropathy(IMN) in adults.Methods:Two hundred and seven patients with HBVMN (n=70) or IMN (n=137) were enrolled in this study. The clinical and pathological results were compared between the two groups.Results:The mean age of the HBVMN group was significantly younger than that of IMN group[(31.7±14.0) years vs (47.1±13.0) years;t=3.533,P<0.001)]. Mesangial proliferation was more commonly observed in HBVMN group than that of IMN group(98.6% vs 69.3%;χ2=24.048,P<0.001),and immunofluorescence discovery of HBVMN group was various immunecomplex deposition, and the deposition of the immunecomplex,IgM,IgA,C3,C1q(χ2=18.175,21.990,16.448,and 50.846,P<0.001), FRA(P=0.007)in the renal tissue between these two groups was statistically significant.Conclusion:Clinical features of HBVMN are similar to those of IMN, but the two groups have their own characteristics in pathology,so the combination of clinical and pathological features is necessary to the diagnosis.

参考文献/References:

[1]中华内科杂志编委会. 乙型肝炎病毒相关性肾炎座谈会纪要[J].中华内科杂志,1990,29(9):519
[2]Gouser WG.Membranous glomerulopathy[M]//Johnson RJ,Feehallin J.Comprehensive clinical nehrology.Philadelphia:Harcourt publishers,2000.
[3]钟鸿斌. 乙型肝炎病毒相关性肾炎发病机制的研究进展[J].国际泌尿系统杂志,2006,26(3):430
[4]Ren J, Wang L, Chen Z, et al. Gene expression profile of transgenic mouse kidney reveals pathogenesis of hepatitis B virus associated nephropathy[J].J Med Virol,2006,78(5):551
[5]吴欣,陶冶.乙型肝炎病毒相关性肾炎研究进展[J].现代临床医学,2007,33(2):153
[6]陈乃玲,朱崇尧,胡德海,等.血清免疫学标志阴性的乙型肝炎病毒携带者及慢性肝病患者的临床意义[J].中华内科杂志,2002,41(10):653

备注/Memo

备注/Memo:
#通讯作者,男,1961年9月生,博士,教授,研究方向:慢性肾功能衰竭的防治,Email:zhangsuoliu@sina.com
更新日期/Last Update: 1900-01-01