[1]赵富周△,杨鲲鹏,庞志刚,等.食管鳞状细胞癌组织中HIF1α、CCR7和VEGFC蛋白的表达[J].郑州大学学报(医学版),2011,(05):660.
 ZHAO Fuzhou,YANG Kunpeng,PANG Zhigang,et al.Expressions of HIF1α,CCR7, and VEGFC in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(05):660.
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食管鳞状细胞癌组织中HIF1α、CCR7和VEGFC蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年05期
页码:
660
栏目:
食管癌研究
出版日期:
2011-09-20

文章信息/Info

Title:
Expressions of HIF1α,CCR7, and VEGFC in esophageal squamous cell carcinoma tissue
作者:
赵富周杨鲲鹏庞志刚张典谷博
郑州大学第二附属医院胸外科 郑州 450014
Author(s):
ZHAO FuzhouYANG KunpengPANG ZhigangZHANG DianGu Bo
Department of Thoracic Surgery,the Second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014
关键词:
食管肿瘤鳞状细胞癌缺氧诱导因子1α趋化因子受体7血管内皮生长因子C淋巴结转移
分类号:
R735.1
摘要:
目的:检测食管鳞状细胞癌(ESCC)组织中缺氧诱导因子1α(HIF1α)、趋化因子受体7(CCR7)及血管内皮生长因子C(VEGFC)蛋白的表达。方法:采用免疫组化SP法检测45例ESCC组织及癌旁正常食管黏膜组织中HIF1α、CCR7及VEGFC蛋白的表达,并分析ESCC组织中3者的表达与临床病理特征的关系。结果:ESCC组织中HIF1α、CCR7及VEGFC蛋白的阳性表达率分别为55.6%、71.1%和64.4%,高于癌旁正常食管黏膜组织的11.1%、17.8%和35.6%(χ2=16.409、17.633和6.261,P均<0.05)。HIF1α、CCR7及VEGFC蛋白的表达与ESCC患者的病理分期和淋巴结转移有关(P<0.05)。ESCC组织中HIF1α的表达与CCR7的表达呈正关联(rP=0.303,P=0.033),CCR7的表达与VEGFC的表达呈正关联(rP=0.409,P=0.003)。结论:ESCC组织中HIF1α、CCR7及VEGFC蛋白的表达上调可能促进了ESCC的侵袭与淋巴结转移。

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备注/Memo

备注/Memo:
△男,1974年9月生,硕士研究生,主治医师,研究方向:食管癌和肺癌的治疗,Email:zhaofuzhou@126.com
更新日期/Last Update: 2011-09-20