[1]陈盼碧△,崔瑾,杨孝芳.不同穴位简易穴位埋线对哮喘大鼠肺组织ICAM1和NFκB表达的影响*[J].郑州大学学报(医学版),2011,(05):677-27.
 CHEN Panbi,CUI Jin,YANG Xiaofang.Effect of simple catgut implantation at different acupoint on expressions of ICAM1 and NFκB in asthmatic rats[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(05):677-27.
点击复制

不同穴位简易穴位埋线对哮喘大鼠肺组织ICAM1和NFκB表达的影响*
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年05期
页码:
677-27
栏目:
论著
出版日期:
2011-09-20

文章信息/Info

Title:
Effect of simple catgut implantation at different acupoint on expressions of ICAM1 and NFκB in asthmatic rats
作者:
陈盼碧崔瑾杨孝芳
贵阳中医学院针灸推拿系 贵阳 550002
Author(s):
CHEN PanbiCUI JinYANG Xiaofang
Department of Acupuncture and Massage,Guiyang College of Traditional Chinese Medicine,Guiyang 550002
关键词:
简易穴位埋线哮喘ICAM1NFκB大鼠
Keywords:
simple catgut implantation at acupointasthmaintercellular adhesion molecule1nuclear transcription factorκBrat
分类号:
R562.2
摘要:
目的:探讨不同穴位简易穴位埋线对哮喘大鼠细胞间黏附分子1(ICAM1)和核转录因子κB(NFκB)表达的影响。方法:Wistar大鼠随机分为简易穴位埋线肺俞膻中组(肺俞膻中组)、肾俞组、肺俞膻中肾俞组、地塞米松组、模型组、对照组,每组8只。除对照组外,余5组卵蛋白致敏制造大鼠哮喘模型。末次诱喘后处死大鼠,免疫组化方法检测6组大鼠肺组织ICAM1和NFκB的表达。结果:6组大鼠肺组织ICAM1和NFκB的相对表达量差异均有统计学意义(F=27.644,27.935,P均<0.001)。肺俞膻中肾俞组哮喘大鼠ICAM1、NFκB表达低于肾俞组、肺俞膻中组(P<0.01和P<0.05),与地塞米松组同效(P>0.05)。结论:集标本兼治于一体的肺俞膻中肾俞穴位埋线对于哮喘大鼠的防治效果明显优于仅治标的肺俞膻中穴位埋线及仅治本的肾俞穴位埋线。
Abstract:
Aim:To explore the effect of simple catgut implantation at different acupoint on ICAM1 and NFκB expression in asthmatic rats.Methods:Fortyeight male Wistar rats were randomly divided into six groups:the simple catgut implantation at acupoint Feishu and Danzhong group(FD group),the simple catgut implantation at acupoint Shenshu group(S group),the simple catgut implantation at acupoint Feishu and Danzhong and Shenshu group (FDS group),dexamethasone group,model group,and control group,and 8 in each group.The asthmatic models were established by ovalbumin except control group.The ICAM1 and NFκB expression levels in bronchioles of all groups were measured by immunohistochemistry.Results:There were significant differences in the expressions of ICAM1 and NFκB in bronchioles among the 6 groups (F=27.644,27.935,P<0.001).The ICAM1 and NFκB expressions in bronchioles of FDS group were lower than those of S group and FD group(P<0.05),similar to dexamethasone group(P>0.05).Conclusion:The implantation at acupoint Feishu,Danzhong and Shenshu has both temporary and permanent effects on asthma,which is better than implantation at acupoint Feishu and Danzhong or at acupoint Shenshu.

参考文献/References:

[1]崔瑾,陈盼碧,杨孝芳,等.简易穴位埋线对哮喘大鼠ICAM1和NFκB表达及气道炎症的影响[J].中国针灸,2010,3(2):141
[2]王妍,金先桥.支气管哮喘实验模型的研究进展[J].国际呼吸杂志,2006,26(1):70
[3]李忠仁.实验针灸学[M].北京:中国中医药出版社,2003:326
[4]许得盛.“温阳片”防治支气管哮喘远期疗效观察[J].上海中医药杂志,1989(12):4
[5]贺志光.中医学[M].3版.北京:人民卫生出版社,1995:500

相似文献/References:

[1]吴景硕),张琳).哮喘患者血清TNFα、IL4与IgE检测[J].郑州大学学报(医学版),2009,(04):904.
[2]王妍炜.普米克令舒联合复方异丙托溴胺雾化吸入治疗小儿支气管哮喘44例[J].郑州大学学报(医学版),2010,(04):680.
 [J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(05):680.
[3]陈景行)△,朱述阳). 罗格列酮对哮喘小鼠气道炎症和肺组织细胞因子信号抑制因子3和5 mRNA表达的影响[J].郑州大学学报(医学版),2011,(02):198.
 CHEN Jinghang),ZHU Shuyang). Effects of rosiglitazone on airway inflammation in asthmatic mice and suppressors of cytokine signaling 3 and 5 mRNA expression in lung tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(05):198.
[4]朱亚蕊,刘剑波#.哮喘小鼠肺和下丘脑组织中γ氨基丁酸受体ARα的表达[J].郑州大学学报(医学版),2012,(02):218.
 ZHU Yarui,LIU Jianbo.Changes of GABAARα expression in lung tissue and hypothalamus of asthmatic mice[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(05):218.
[5]史玲艾,袁洁,安淑华#,等.哮喘儿童应用粉尘螨滴剂舌下含服脱敏治疗的随访观察[J].郑州大学学报(医学版),2012,(02):267.
 SHI Lingai,YUAN Jie,AN Shuhua,et al.Followup of sublingual desensitization therapy in children with asthma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(05):267.
[6]张铁栓),张国俊)#,刘颖).还原型谷胱甘肽对哮喘豚鼠气道上皮细胞的保护作用[J].郑州大学学报(医学版),2013,(01):70.
 ZHANG Tieshuan,ZHANG Guojun,LIU Ying.Protective function of reducing glutathione on airway epithelial cells in guinea pig models of asthma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(05):70.
[7]张艳丽△,王秀芳,乔俊英,等.哮喘患儿外周血髓系抑制细胞、IL10和IL12水平检测*[J].郑州大学学报(医学版),2013,(04):502.
 ZHANG Yanli,WANG Xiufang,QIAO Junying,et al.Detection of MDSCs, IL10, and IL12 levels in peripheral blood from children with asthma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(05):502.
[8]车 楠,叶 晶,姜京植,等.黑米花色苷对哮喘小鼠气道炎症的影响[J].郑州大学学报(医学版),2018,(01):30.[doi:10.13705/j.issn.1671-6825.2017.60.002]
 CHE Nan,YE Jing,JIANG Jingzhi,et al.Effects of anthocyanin-rich extract from black rice on airway inflammation in asthmatic mice[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(05):30.[doi:10.13705/j.issn.1671-6825.2017.60.002]

备注/Memo

备注/Memo:
*贵州省教育厅自然科学研究项目黔教科2006316 △女,1982年9月生,讲师,硕士,研究方向:针灸适宜技术,Email:chenpanbi@126.com
更新日期/Last Update: 2011-09-20