[1]宋新强△,汪学群,易朝辉,等.豫南地区汉族人群类风湿性关节炎患者TNFα基因启动子-308 G/A多态性检测*[J].郑州大学学报(医学版),2011,(05):691-40.
 SONG Xinqiang,WANG Xuequn,YI Zhaohui,et al.Detection of TNFα gene promoter -308 G/A polymorphism in Han population with rheumatoid arthritis in the South of Henan province[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(05):691-40.
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豫南地区汉族人群类风湿性关节炎患者TNFα基因启动子-308 G/A多态性检测*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年05期
页码:
691-40
栏目:
论著
出版日期:
2011-09-20

文章信息/Info

Title:
Detection of TNFα gene promoter -308 G/A polymorphism in Han population with rheumatoid arthritis in the South of Henan province
作者:
宋新强1 汪学群2 易朝辉3郑健1韩俊刚1刘承丽1张亚可1彭玉玲1马云1
1)信阳师范学院生命科学学院 信阳 464000 2)信阳市第一人民医院风湿免疫科 信阳 464000 3)信阳职业技术学院 信阳 464000
Author(s):
SONG Xinqiang1 WANG Xuequn2 YI Zhaohui3 ZHENG Jian1 HAN Jungang1 LIU Chengli1 ZHANG Yake1 PENG Yuling1 MA Yun1
1)College of Life Sciences, Xinyang Normal University, Xinyang 464000 2)Department of Rheumatism and Immunology,the First People’s Hospital of Xinyang, Xinyang 4640003)Xinyang Vocational and Technical College,Xinyang 464000
关键词:
肿瘤坏死因子α类风湿性关节炎基因多态性
Keywords:
tumor necrosis factorαrheumatoid arthritisgene polymorphisms
分类号:
R392.2
摘要:
目的:探讨肿瘤坏死因子α(TNFα)基因启动子-308 G/A多态性与豫南地区汉族人群类风湿性关节炎(RA)的相关性。方法:采用聚合酶链反应限制性片段长度多态性(PCRRFLP)技术分析90例RA患者及100例正常对照TNFα基因启动子-308 G/A多态性。结果:RA患者与正常对照相比,-308基因型频率和等位基因频率差异无统计学意义(P均>0.05);RA患者组中有侵蚀性病变患者-308位点G等位基因频率与无侵蚀性病变患者相比差异有待进一步研究(χ2=4.074,P=0.044)。结论:TNFα基因启动子-308 G/A多态性可能与豫南地区汉族人群RA无关,但可能与关节的侵蚀性病变有关。
Abstract:
Aim:To study the relationship between TNFα gene promoter -308 G/A polymorphism and rheumatoid arthritis(RA) in the South of Henan province.Methods:A total of 90 cases with RA(patient group) and 100 healthy subjects(control group) were recruited.The -308 G/A polymorphism of TNFα gene promoter was analyzed by PCRRFLP.Results:There were no significant differences in genotype frequency and allele frequency between patient group and control group (P>0.05).But there was significant difference in the -308 G allele frequency between erosive RA patients and nonerosive RA patients (χ2=4.074,P=0.044).Conclusion:The -308 G/A polymorphism of TNFα gene promoter is not associated with RA in Han population form South of Henan province, but maybe associated with the erosive lesion of RA.

参考文献/References:

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备注/Memo

备注/Memo:
*国家自然科学基金青年基金资助项目30801010;河南省教育厅科技计划基金资助项目2009A180017;信阳师范学院青年科研基金资助项目20080207 △男,1974年5月生,博士,讲师,研究方向:类风湿性关节炎的发病机制与治疗,Email:xqsong2002@yahoo.com
更新日期/Last Update: 2011-09-20