[1]霍志芳,陈魁#,阎西艴,等.冠心病患者血清趋化因子和白细胞介素18水平分析[J].郑州大学学报(医学版),2011,(05):717-76.
 HUO Zhifang,CHEN Kui,YAN Xifu,et al.Levels of serum FKN and interleukin18 in patients with coronary heart disease[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(05):717-76.
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冠心病患者血清趋化因子和白细胞介素18水平分析
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年05期
页码:
717-76
栏目:
论著
出版日期:
2011-09-20

文章信息/Info

Title:
Levels of serum FKN and interleukin18 in patients with coronary heart disease
作者:
霍志芳陈魁#阎西艴党瑜华姜正明秦立赵国鲜牛丽莉申泱泱
郑州大学第一附属医院心内科 郑州 450052
Author(s):
HUO ZhifangCHEN KuiYAN XifuDANG YuhuaJIANG ZhengmingQIN LiZHAO GuoxianNIU LiliSHENG Yangyang
Department of Cardiology, the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
冠心病趋化因子白细胞介素18
Keywords:
coronary heart diseasefractalkineinterleukin18
分类号:
R543.3
摘要:
目的:检测冠心病(CHD)患者血清趋化因子(FKN)和白细胞介素18(IL18)水平。方法:经冠脉造影确诊的CHD患者62例,其中稳定性心绞痛32例(SAP组),急性冠脉综合征30例(ACS组);另选经冠脉造影排除CHD者21例为对照。用酶联免疫吸附法测定各组患者血清FKN和IL18的水平;记录Gensini积分,评价各组患者冠状动脉狭窄的严重程度。结果:3组患者血清FKN、IL18水平gensini积分差异有统计学意义(P均<0.001)。与对照组和SAP组相比,ACS组血清FKN 和IL18水平升高(P<0.01)。CHD患者血清FKN水平与IL18水平呈正相关(r=0.776,P<0.001),与gensini积分弱相关(rs=0.269,P=0.034)。结论:血清FKN和IL18是CHD发病过程中的重要炎症介质,可能在ACS的发展中起重要作用。
Abstract:
Aim:To investigate the changes of fractalkine(FKN) and interleukin18(IL18) in serum of patients with coronary heart disease(CHD) and explore the clinical significance.Methods:A total of 32 cases of stable angina pectoris(SAP),30 cases of acute coronary syndrome(ACS),and 21 cases control were collected.ELISA was used to detect the serum levels of FKN and IL18,and gensini score was recorded.Results: There were significant differences in serum levels of FKN,IL18 and gensini score among the three groups(F was 46.871,and 291.386,H=70.194,all P<0.001).The serum level of FKN significantly increased in ACS group compared with those of control group and SAP group(P<0.01).Liner regression showed that the serum FKN level of CHD patients was related to IL18(r=0.776,P<0.001),and weakly related to gensini score(rs=0.269,P=0.034).Conclusion:FKN and IL18 may play important roles in the development of ACS.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1962年1月生,博士,教授,研究方向:冠心病的基础与临床,Email:chenkui@hotmail.com
更新日期/Last Update: 2011-09-20