[1]刘新贵,武玉东#,孙莹璞,等.血清FSH水平和T/LH比值对无精子症患者精子获得的预测作用[J].郑州大学学报(医学版),2011,(05):732-96.
 LIU Xingui,WU Yudong,SUN Yingpu,et al.Predictable value of serum FSH and T/LH ratio in sperm obtained rate of azoospermia patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(05):732-96.
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血清FSH水平和T/LH比值对无精子症患者精子获得的预测作用
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年05期
页码:
732-96
栏目:
论著
出版日期:
2011-09-20

文章信息/Info

Title:
Predictable value of serum FSH and T/LH ratio in sperm obtained rate of azoospermia patients
作者:
刘新贵1武玉东2# 孙莹璞1王芳1李刚1
1)郑州大学第一附属医院生殖中心 郑州 450052 2)郑州大学第一附属医院泌尿外科 郑州 450052
Author(s):
LIU Xingui1WU Yudong2SUN Yingpu1WANG Fang1LI Gang1
1)Reproductive Medical Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Urology, the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
促卵泡生长素雄激素/促黄体生成素比值无精子症
Keywords:
FSHT/LH ratioazoospermia
分类号:
R698.2
摘要:
目的:评价血清促卵泡生长素(FSH)水平和雄激素(T)/促黄体生长素(LH)比值2项检测指标联合在实施辅助生殖前对无精子症患者精子获得的预测作用。方法:209例已实施人类辅助生殖技术(ART)的无精子症患者[病理诊断梗阻性无精子症(OA) 138例,非梗阻性无精子症(NOA)71例],回顾分析OA和NOA患者FSH、LH、泌乳素(PRL)和T等激素水平和T/LH值的变化。比较指标联合(FSH和T/LH)进行分型诊断与病理诊断结果之间的符合率差异,同时比较联合预测方法与PESA/TESA方法在预测精子获得上的一致性。结果:NOA患者FSH、LH值均高于OA患者(t=15.989和9.074,P<0.001),而T、T/LH均低于OA患者(t=4.355和11.092,P<0.001)。该诊断在的灵敏度为97.101%、特异度为90.141%、假阳性率为2.899%和假阴性率为9.859%。 指标联合预测与PESA/TESA方法对区分OA和NOA结果一致(Kappa=0.861,P<0.001)。结论:血清FSH和T/LH比值2项指标联合对无精子症患者进行分型诊断和预测患者有无精子准确、简便、易行。
Abstract:
Aim:To evaluate the two test markers (serum FSH level and T/LH ratio) in predicting the sperm obtained rate before the implementation of assisted reproduction technology of azoospermia patients.Methods:A total of 209 azoospermia patients,who had been implemented ART,were divided into nonobstructive azoospermia (NOA) and obstructive azoospermia (OA) groups according to pathological diagnosis. Retrospective analysis of the levels of FSH,LH,PRL and T in each group.Results:The FSH, LH values in NOA group were significantly higher than that in OA group (t=15.989 and 9.074,P<0.001),T,T/LH ratio were significantly lower than that in OA group (t=4.355 and 11.092,P<0.001).There were no difference in sperm positive rates of two test markers prediction method and PESA/TESA method(Kappa=0.861,P<0.001).Conclusion:The two test markers of serum FSH,T/LH ratio are useful to predict the sperm obtaining of azoospermia. It is a more accurate, simple and easy method in assisted reproductive technology.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1966年9月生,博士,教授,研究方向:泌尿生殖系肿瘤的基础与临床,Email:wydkw@163.com
更新日期/Last Update: 2011-09-20