[1]张书伟,张莉蓉#.两头毛水提物对衰老小鼠心、肝及肾组织中MDA、GSH和SOD含量的影响[J].郑州大学学报(医学版),2011,(05):735.
 ZHANG Shuwei,ZHANG Lirong.Effects of water extract from incarvillea arguta royle on levels of MDA,GSH and SOD in heart,liver and kidney of mice[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(05):735.
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两头毛水提物对衰老小鼠心、肝及肾组织中MDA、GSH和SOD含量的影响
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年05期
页码:
735
栏目:
论著
出版日期:
2011-09-20

文章信息/Info

Title:
Effects of water extract from incarvillea arguta royle on levels of MDA,GSH and SOD in heart,liver and kidney of mice
作者:
张书伟张莉蓉#
郑州大学基础医学院药理学教研室 郑州 450001
Author(s):
ZHANG ShuweiZHANG Lirong
Department of Pharmacology,College of Basic Medical Sciences,Zhengzhou University, Zhengzhou 450001
关键词:
两头毛水提物抗氧化氧自由基小鼠
Keywords:
water extract from incarvillea arguta royleantioxidativeoxygen free radicalsmouse
分类号:
R284
摘要:
目的:探讨两头毛水提物(IARWater)的抗氧化活性及抗氧化机制。方法:72只小鼠分成6组,每组12只,分别为空白组,模型组,阳性药物维生素E组(200 mg/kg), IARWater低、中和高剂量(分别相当于药材1.9、3.8和7.6 g/kg)组,给药同时,模型组、阳性药物维生素E组、IARWater低、中和高剂量组小鼠每天颈背部皮下注射D半乳糖1 g/(kg·d)建立衰老小鼠模型,空白组皮下注射等体积注射用水。7周后对小鼠心、肝和肾组织中丙二醛(MDA)、超氧化物歧化酶(SOD)和还原型谷胱甘肽(GSH)的含量进行测定。结果:各组小鼠心、肝、肾中MDA、SOD和GSH的含量比较,差异有统计学意义(P<0.05)。与模型组比较,阳性药物维生素E组和IARWater中和高剂量组心、肝、肾组织中MDA的含量下降,SOD和GSH的含量升高(P<0.05)。结论:IARWater可能通过清除羟自由基而发挥抗氧化作用。
Abstract:
Aim: To study the antioxidative activity and its mechanism of the water extract from incarvillea arguta royle(IAR).Methods:A total of 72 mice were randomly divided into six groups(12 mice in each group):the normal group, model group, positive medicine vitamin E group (200 mg/kg), IARWater low,medium,high dose group (equivalent drugs 1.9,3.8,7.6 g/kg). At the same time of administration, the model group,positive control group and reagent mice were injected Dgalactose 1g/(kg·d) by SC, the normal group was injected the same volume of water.Seven weeks after administration,the levels of malondialdehyde(MDA), superoxide dismutase(SOD),and glutathione peroxidase(GSH) in tissues of heart,liver,and kidney were detected.Results:The levels of MDA, SOD,and GSH of 6 groups in tissues of heart,liver,and kidney were obviously different (P<0.05). The levels of MDA were lower and the levels of SOD and GSH were higher in positive medicine vitamin E group,IARWater medium, high dose groups than those in model group(P<0.05).Conclusion:IAR water extract has the antioxidative activity by eliminating oxygen free radicals.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,女,1964年10月生,博士,教授,研究方向:临床药理学,Email:lrz@zzu.edu.cn
更新日期/Last Update: 2011-09-20