[1]葛晓晴,任景丽#,杨鲲鹏,等.肺鳞状细胞癌组织中磷酯酶CE1的表达[J].郑州大学学报(医学版),2011,(05):737.
 GE Xiaoqing,REN Jingli,YANG Kunpeng,et al.Expression of phospholipase C epsilon1 in lung squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(05):737.
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肺鳞状细胞癌组织中磷酯酶CE1的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年05期
页码:
737
栏目:
论著
出版日期:
2011-09-20

文章信息/Info

Title:
Expression of phospholipase C epsilon1 in lung squamous cell carcinoma tissue
作者:
葛晓晴1任景丽2#杨鲲鹏1王旭广1黄壮士1张进1陈培楠1谷博1王立东3
1)郑州大学第二附属医院胸外科 郑州 450014 2) 郑州大学第二附属医院病理科 郑州 450014 3)河南省食管癌重点开放实验室 郑州 450052
Author(s):
GE Xiaoqing1REN Jingli2YANG Kunpeng1WANG Xuguang1HUANG Zhuangshi1ZHANG Jin1CHEN Peinan1GU Bo1WANG Lidong3
1)Department of Thoracic Surgery,the Second Affiliated Hospital, Zhengzhou University,Zhengzhou 4500142)Department of Pathology,the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 4500143)Henan Key Laboratory for Esophageal Cancer Research,Zhengzhou 450052
关键词:
磷酯酶CE1鳞状细胞癌肺肿瘤
Keywords:
phospholipase C epsilon1squamous cell carcinomalung neoplasm
分类号:
R734.2
摘要:
目的:探讨磷酯酶CE1(PLCE1)在肺鳞状细胞癌组织中的表达及意义。方法:采用免疫组化SP法检测48例肺鳞状细胞癌组织和48例正常肺组织中PLCE1的表达,分析其表达与肺鳞状细胞癌组织临床病理特征的关系。结果:肺鳞状细胞癌组织中PLCE1的阳性表达率为81.3%(39/48),高于正常肺组织的12.5%(6/48)(χ2=26.561,P<0.001)。PLCE1的表达与肺鳞状细胞癌淋巴结转移和肿瘤分期有关(χ2=6.274和4.255,P<0.05),而与性别、年龄、肿瘤分化程度无关(P>0.05)。结论:PLCE1可能与肺鳞状细胞癌的发生、发展相关,PLCE1蛋白检测可能有助于肺鳞状细胞癌的预后判断。
Abstract:
Aim:To study the expression of phospholipase C epsilon1 (PLCE1) in lung squamous cell carcinoma tissue and its clinical significance.Methods:The expression of PLCE1 protein in 48 cases of lung squamous cell carcinoma tissues and 48 cases of normal lung tissues was examined by immunohistochemical SP staining.Results:The positive expression rate of PLCE1 in lung carcinoma tissue was 81.3%, higher than that in normal lung tissue (12.5%,χ2=26.561,P<0.001).The expression of PLCE1 was related with tumor lymph node metastasis and tumor staging (χ2=6.274,4.255,P<0.05),but not with gender,age or tumor differentiation(P>0.05).Conclusion: High expression of PLCE1 may be associated with the occurrence and development of lung carcinoma. Detection of PLCE1 has important clinical significance for prediction of lung carcinoma.

参考文献/References:

[1]Wang LD,Zhou FY,Li XM, et al. Genomewide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54[J]. Nat Genet, 2010, 42 (9): 759
[2]江晓红,徐黎明,许林杰. 几种免疫组化检测系统在免疫组化中的应用 [J]. 浙江中医药大学学报, 2009, 33(6):795
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[4]王晓亮,彭志海. 磷酯酶C家族新成员磷酯酶CE1 [J]. 医学分子生物学杂志, 2008,5(4):332
[5]Bai Y,Edamatsu H,Maeda S, et al. Crucial role of phospholipase Cepsilon in chemical carcinogeninduced skin tumor development [J]. Cancer Res,2004,64(24):8808
[6]Sorli SC,Bunney TD,Sugden PH,et al.Signaling properties and expression in normal and tumor tissues of two phospholipase Cepsilon splice variants[J].Oncogene,2005,24(1):902
[7]Ou L,Guo Y,Luo C,et al.RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line [J]. Cancer Genet Cytogenet,2010,200(2):110
[8]Chaib H,Hoskins BE,Ashraf S, et al. Identification of BRAF as a new interactor of PLCepsilon1, the protein mutated in nephrotic syndrome type 3 [J]. Am J Physiol Renal Physiol, 2008,294(1):F93
[9]Jefferson JA,Shankland SJ.Familial nephrotic syndrome:PLCE1 enters the fray[J].Nephrol Dial Transplant,2007,22(7):1849

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备注/Memo

备注/Memo:
葛晓晴1),任景丽2)#,杨鲲鹏1),王旭广1),黄壮士1),张进1),陈培楠1),谷博1),王立东3)
更新日期/Last Update: 2011-09-20