[1]张思森),张谢夫)﹟,张云汉).食管鳞状细胞癌组织中PTEN、Ecadherin和CD44v6蛋白的表达[J].郑州大学学报(医学版),2011,(06):817.
 ZHANG Sisen),ZHANG Xiefu),ZHANG Yunhan).Expressions of PTEN, Ecadherin and CD44v6 in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(06):817.
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食管鳞状细胞癌组织中PTEN、Ecadherin和CD44v6蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年06期
页码:
817
栏目:
食管癌研究
出版日期:
2011-11-20

文章信息/Info

Title:
Expressions of PTEN, Ecadherin and CD44v6 in esophageal squamous cell carcinoma tissue
作者:
张思森12)张谢夫1)张云汉3)
1)郑州大学第一附属医院普通外科 郑州 450052 2)郑州人民医院普通外科 郑州 450003 3)郑州大学第一附属医院病理科;河南省肿瘤病理重点实验室 郑州 450052
Author(s):
ZHANG Sisen12) ZHANG Xiefu1)ZHANG Yunhan3)
1)Department of General Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of General Surgery,Zhengzhou People’s Hospital, Zhengzhou 4500033)Department of Pathology, the First Affiliated Hospital, Zhengzhou University; Henan Key Laboratory for Tumor Pathology, Zhengzhou 450052
关键词:
PTENEcadherinCD44v6食管肿瘤鳞状细胞癌
分类号:
R735.1
摘要:
目的:探讨PTEN、Ecadherin和CD44v6蛋白表达与食管癌临床病理因素的关系。方法:采用免疫组织化学SP法分别检测39例食管正常黏膜、23例癌旁不典型增生和52例食管鳞状细胞癌组织中PTEN、Ecadherin和CD44v6蛋白的表达水平。结果:食管正常黏膜、癌旁不典型增生和食管鳞状细胞癌组织中PTEN、Ecadherin蛋白阳性表达率逐渐降低(χ2=14.322,21.622,P<0.001),CD44v6蛋白阳性表达率逐渐升高(χ2=19.372,P<0.001)。PTEN、Ecadherin阳性表达率随癌组织分化程度的降低而降低(P<0.01),随浸润深度的增加而降低(P<0.05);有淋巴结转移者PTEN、Ecadherin阳性表达率低于无淋巴结转移者(χ2=9.871和6.502,P=0.002和0.011)。CD44v6阳性表达率随癌组织分化程度的降低和浸润深度的增加而逐渐升高(P<0.05),有淋巴结转移者CD44v6阳性表达率高于无淋巴结转移者(χ2校正=4.442,P=0.035)。癌组织中Ecadherin、PTEN与CD44v6的表达呈负关联(rp=0.585,0.531,P<0.001),PTEN与Ecadherin的表达呈正关联(rp=0.601,P<0.001)。结论:PTEN、Ecadherin和CD44v6的异常表达参与了食管鳞状细胞癌的发生、发展和浸润转移。

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1957年6月生,博士,教授,主任医师, 研究方向:消化道肿瘤基础与临床研究,Email: zhangxiefu@medmail.com.cn
更新日期/Last Update: 1900-01-01