[1]陈飞,高艳锋,朱宇皇,等.结核分枝杆菌耐药相关药物外排抗原HLAA2限制性细胞毒性T淋巴细胞表位预测*[J].郑州大学学报(医学版),2011,(06):839.
 CHEN Fei,GAO Yanfeng,ZHU Yuhuang,et al.Prediction of HLAA2 restricted cytotoxic T lymphocyte epitopes in Mycobecterium tuberculosis drug efflux antigens[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(06):839.
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结核分枝杆菌耐药相关药物外排抗原HLAA2限制性细胞毒性T淋巴细胞表位预测*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年06期
页码:
839
栏目:
论著
出版日期:
2011-11-20

文章信息/Info

Title:
Prediction of HLAA2 restricted cytotoxic T lymphocyte epitopes in Mycobecterium tuberculosis drug efflux antigens
作者:
陈飞高艳锋朱宇皇祁元明#
郑州大学生物工程系 郑州 450001
Author(s):
CHEN FeiGAO YanfengZHU Yuhuang QI Yuanming
Department of Bioengineering, Zhengzhou University, Zhengzhou 450001
关键词:
结核分枝杆菌药物外排抗原表位预测
Keywords:
Mycobacterium tuberculosisdrug efflux antigenepitope prediction
分类号:
R52
摘要:
目的:预测结核分枝杆菌(MTB)耐药相关药物外排抗原(Rv1634、Rv2846c、Rv2937、Rv2686c、Rv2687c及Rv3065)的HLAA2限制性细胞毒性T淋巴细胞(CTL)表位。方法:通过NCBI数据库获取目的蛋白的氨基酸序列,运用BLAST分析它们与人类蛋白的同源性,利用SYFPEITHI、BIMAS和NetCTL数据库软件预测HLAA2限制性CTL表位。结果与结论:预测筛选出6个候选抗原的21个HLAA2限制性CTL优势表位。
Abstract:
Aim:To predict the HLAA2 restricted CTL epitopes in Mycobacterium tuberculosis drug efflux antigens(Rv1634, Rv2846c, Rv2937, Rv2686c, Rv2687c, and Rv3065).Methods:The amino acid sequences of the antigens were obtained from NCBI database. Their homology to human proteins was analyzed by BLAST. HLAA2 restricted T lymphocyte epitopes were predicted by SYFPEITHI, BIMAS,and NetCTL.Results and Conclusion:A total of 21 predominant HLAA2 restricted T lymphocyte epitopes were predicted from the six candidate antigens.

参考文献/References:

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目30872381;河南省杰出人才基金资助项目084200510014 #通讯作者,女,1957年1月生,博士,教授,研究方向:抗原肽和多肽疫苗,Email:qym@zzu.edu.cn
更新日期/Last Update: 1900-01-01