[1]张振香)△,林蓓蕾),陈颖),等.外周穿刺中心静脉置管术患者炎症细胞因子和凝血四项水平分析*[J].郑州大学学报(医学版),2011,(06):849.
 ZHANG Zhenxiang,LIN Beilei,CHEN Ying,et al.Levels of inflammatory cytokines and 4 coagulation parameters of patients with PICC[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(06):849.
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外周穿刺中心静脉置管术患者炎症细胞因子和凝血四项水平分析*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年06期
页码:
849
栏目:
论著
出版日期:
2011-11-20

文章信息/Info

Title:
Levels of inflammatory cytokines and 4 coagulation parameters of patients with PICC
作者:
张振香1)林蓓蕾1)陈颖2)王艳丽2)杨巧芳3)程瑞莲4)高峰5)
1)郑州大学护理学院 郑州 450001 2)郑州大学第二附属医院感染疾病科 郑州 450014 3)河南省人民医院老年医学临床部 郑州 450003 4)郑州人民医院神经内科 郑州 450014 5)河南省医药科学研究院神经免疫实验室 郑州 450052
Author(s):
ZHANG Zhenxiang1)LIN Beilei1)CHEN Ying2)WANG Yanli2)YANG Qiaofang3)CHENG Ruilian4)GAO Feng5)
1)Nursing College,Zhengzhou University,Zhengzhou 450001 2)Department of Infection,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014 3)Department of Clinical Geriatric Medicine,Henan Provincial People’s Hospital,Zhengzhou 450003 4)Department of Neurolgoy,Zhengzhou City People's Hospital,Zhengzhou 450014 5)Department of Neurology and Immunity,Henan Academy of Medical and Pharmacologic Sciences,Zhengzhou 450052
关键词:
外周穿刺中心静脉置管术炎症细胞因子凝血
Keywords:
peripherally inserted central catheterinflammatory cytokinecoagulation
分类号:
R472.9
摘要:
目的:探讨外周穿刺中心静脉置管术(PICC)患者血清TNFα、IL6、IL10及凝血四项水平的变化。方法:以未PICC患者38例为对照(包括肿瘤患者10例、非肿瘤患者18例和血液病患者10例),对比分析PICC患者(包括肿瘤患者14例、非肿瘤患者20例和血液病患者16例)炎症细胞因子TNFα、IL6、IL10和凝血四项水平的变化。放射免疫法测定血浆TNFα、IL6水平,酶联免疫吸附试验测定IL10,全自动血凝仪测定凝血四项。结果:PICC肿瘤、非肿瘤、血液病组TNFα水平高于相应未PICC对照组(t分别为2.330、3.606和3.110,P均<0.05),IL6水平低于相应对照组(t分别为7.120、5.863 和2.572,P均<0.05),IL10水平无明显变化(t分别为0.881、0.887和0.079,P均>0.05);非肿瘤PICC组凝血四项与未PICC对照组比较,差异均无统计学意义(P均>0.05)。结论:PICC置管后血浆TNFα水平的升高和IL6水平的下降可能与静脉血栓形成有关。
Abstract:
Aim:To investigate the the changes of the levels of TNFα, IL6, IL10,and coagulation parameters in serum of peripherally inserted central catheter(PICC) patients.Methods:A total of 38 patients not performed PICC(including 10 patients with tumor,18 patients without tumor,and 10 patients with blood diseases) and 50 patients with PICC (including 14 patients with tumor,20 without tumor and 16 with blood diseases),were collected and the levels of TNFα and IL6 in serum were determined by radioimmunoassay,the level of IL10 by ELISA,and with the level of coagulation parameters by automatic coagulation machine.Results:Compared with the control groups,the levels of TNFα of PICC patients with tumor,without tumor,and with blood diseases were higher(t=2.330,3.606,and 3.110,P<0.05),and the levels of IL6 were lower(t=7.120,5.863,and 2.572,P<0.05),but the levels of IL10 had no significant difference(t=0.881,0.887,and 0.079,P>0.05).The levels of coagulation parameters of nontumor PICC group had not changed significantly(P>0.05).Conclusion:TNFα becomes more higher and IL6 becomes more lower after PICC,suggesting PICC may lead to venous inflammation and then result in thrombosis.

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备注/Memo

备注/Memo:
*河南省基础与前沿技术研究计划项目资助课题092300410223 △女,1961年6月生,硕士,教授,研究方向:内科护理,Email:Zhangzx6666@126.com
更新日期/Last Update: 1900-01-01