[1]王梦涵),卢宏)#,焦淑洁),等.多发性硬化患者血清激肽释放酶1和6水平分析[J].郑州大学学报(医学版),2011,(06):885.
 WANG Menghan),LU Hong),JIAO Shujie),et al.Determination of serum kallikrein 1 and kallikrein 6 levels in patients with multiple sclerosis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(06):885.
点击复制

多发性硬化患者血清激肽释放酶1和6水平分析
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年06期
页码:
885
栏目:
论著
出版日期:
2011-11-20

文章信息/Info

Title:
Determination of serum kallikrein 1 and kallikrein 6 levels in patients with multiple sclerosis
作者:
王梦涵1)卢宏1)# 焦淑洁1)杜冉1)蒋超2)刘希2)
1)郑州大学第一附属医院神经内科 郑州 4500522)郑州大学第五附属医院神经内科 郑州 450052
Author(s):
WANG Menghan1)LU Hong1)JIAO Shujie1)DU Ran1)JIANG Chao2)LIU Xi2)
1)Department of Neurology, the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Neurology, the Fifth Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
激肽释放酶1激肽释放酶6多发性硬化复发
Keywords:
kallikrein 1kallikrein 6multiple sclerosisrelapse
分类号:
R744.5+1
摘要:
目的:测定多发性硬化(MS)初发组与复发组患者血清激肽释放酶1(klk1)与激肽释放酶6(klk6)的水平,研究二者与MS复发的关系。方法:采用ELISA法测定健康对照者、其他神经系统疾病患者、初发MS患者和复发MS患者各50名外周血血清klk1和klk6水平。结果:4组患者血清klk1和klk6水平比较,差异均有统计学意义(F=158.940和61.490,P<0.001);MS初发组与复发组血清klk1和klk6水平均高于其他2组, 且MS复发组高于初发组(P<0.05)。MS患者血清klk1、klk6水平分别与MS的复发呈正关联(rP=0.555和0.447,P<0.05)。结论:血清klk1、klk6水平与MS复发相关,可能作为反映MS复发的指标。
Abstract:
Aim:To determine the serum levels of kallikrein 1(klk1) and kallikrein 6(klk6) in the multiple sclerosis(MS) patients with initial attack and patients with recurrent attack,so as to investigate the role of klk1 and klk6 in the relapse process of MS.Methods:ELISA method was used to detect the klk1 and klk6 levels in the serum of 50 MS patients with initial attack and 50 MS patients with recurrent attack, as well as other neurological diseases controls and normal controls.Results:The serum klk1 and klk6 levels among the 4 groups had significant differences(F=158.940 and 61.490,P<0.001).The klk1 and klk6 levels in the serum of the MS patients with initial attack and MS patients with recurrent attack were significantly higher than those of the other 2 groups(P<0.05),and those of recurrent group were also significantly higher than the initial group(P<0.05).Serum klk1 and klk6 levels and disease recurrence were positively correlated(rP=0.555 and 0.447,P<0.05).Conclusion:The serum levels of klk1 and klk6 have correlation with the relapse of MS, and klk1 and klk6 can be served as markers to reflect the relapse of MS.

参考文献/References:

[1]卢德宏,汤国才.多发性硬化的临床病理学[J].实用儿科临床杂志,2005,20(4):293 [2]Guo MF,Ji N,Ma CG. Immunologic pathogenesis of multiple sclerosis[J].Neurosci Bull,2008,24(6):381 [3]刘佩峰,赵永波. 多发性硬化轴索和神经元变性[J].中国神经免疫学和神经病学杂志,2004,11(5):286 [4]Polman CH,Reingold SC,Edan G,et al.Diagnostic criteria for multiple sclerosis:2005 revisions to the “McDonald Criteria”[J].Ann Neurol,2005,58(6):840 [5]Scarisbrick LA,Linbo R,Vandell AG,et al.Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration[J].Biol Chem,2008,389(6):739 [6]娄江涛,胡成进.组织型激肽释放酶及相关肽酶在中枢神经系统中的作用[J].生命的化学,2010,30(2):307 [7]Hartung HP,Kieseier BC.The role of matrix metalloproteinases in autoimmune damage to the central and peripheral nervous system[J].J Neuroimmunol,2000,107(2):140 [8]Terayama R,Bando Y,Jiang YP,et al. Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis[J]. Neurosci Lett,2005,382(1/2):82 [9]Hebb AL,Bhan V,Wishart AD,et al. Human kallikrein 6 cerebrospinal levels are elevated in multiple sclerosis[J] .Curr Drug Discov Technol,2010,7(2):137

备注/Memo

备注/Memo:
#通讯作者,女, 1965年4月生,博士,教授,主任医师,研究方向:脑血管病的基础与临床研究,Email: zhiyusong@yeah.net
更新日期/Last Update: 1900-01-01