[1]务森,张谢夫#,赵春临,等.胃肠道间质瘤组织中Ki67、Cyclin D1、ICAM1、Livin及MMP9蛋白表达与危险度分级[J].郑州大学学报(医学版),2011,(06):895.
 WU Sen,ZHANG Xiefu,ZHAO Chunlin,et al.Relationship between the expressions of Ki67,Cyclin D1,Livin,ICAM1,MMP9 and Fletcher’s classification in gastrointestinal stromal tumors[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(06):895.
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胃肠道间质瘤组织中Ki67、Cyclin D1、ICAM1、Livin及MMP9蛋白表达与危险度分级
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年06期
页码:
895
栏目:
论著
出版日期:
2011-11-20

文章信息/Info

Title:
Relationship between the expressions of Ki67,Cyclin D1,Livin,ICAM1,MMP9 and Fletcher’s classification in gastrointestinal stromal tumors
作者:
务森张谢夫#赵春临刘涛
郑州大学第一附属医院普外科 郑州 450052
Author(s):
WU SenZHANG XiefuZHAO ChunlinLIU Tao
Department of General Surgery,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
胃肠道间质瘤Ki67细胞周期素 D1细胞间黏附分子凋亡抑制蛋白基质金属蛋白酶9
Keywords:
gastrointestinal stromal tumor Ki67 Cyclin D1 Livin ICAM1 MMP9
分类号:
R735.2
摘要:
目的:探讨胃肠道间质瘤组织中Ki67、细胞周期素D1(Cyclin D1)、细胞间黏附分子(ICAM1)、凋亡抑制蛋白(Livin)及基质金属蛋白酶9(MMP9)蛋白表达与Fletcher分级的相关性。方法:应用免疫组化SP法检测67例胃肠道间质瘤存档蜡块标本中各蛋白的表达情况,单因素和多因素分析各蛋白表达与Fletcher分级的关系。结果:单因素分析结果显示,不同危险度分组中,Ki67、Cyclin D1、Livin及MMP9蛋白表达的差异有统计学意义(P均<0.05)。有序Logistic回归多因素分析结果显示,Cyclin D1和MMP9对Fletcher分级影响显著,是Fletcher分级的独立影响因子, Cyclin D1和MMP9的优势比分别为3.51和3.29。结论:Cyclin D1、MMP9蛋白在胃肠道间质瘤组织中的表达与Fletcher分级具有明确的相关性,可作为判定恶性程度的参照因素。
Abstract:
Aim:To investigate the relationship between the expressions of Ki67,Cyclin D1,Livin,ICAM1,MMP9 and Fletcher’s classification in gastrointestinal stromal tumors(GISTs).Methods:The expressions of Ki67, Cyclin D1,Livin, ICAM1 and MMP9 were detected by SP staining in 67 cases of GISTs. The relationship between the proteins expressions and Fletecher risk rank were analyzed.Results:Univariate analyses revealed differences of Ki67, Cyclin D1, Livin and MMP9 expressions were statistical significant in the different risk groups (all P<0.05). Logistic regression model revealed the expressions of Cyclin D1, MMP9 impacted Fletcher’s classification significantly(OR:3.51 and 3.29).Conclusion:There was clear correlation between the expressions of Cyclin D1,MMP9 and Fletcher’s classification in GISTs,they can be used as independent predicting factors of malignancy degrees.

参考文献/References:

[1]张信华,何裕隆,詹文华,等.胃肠间质瘤135例临床诊治分析[J].中华胃肠外科杂志,2007,10(1):17 [2]张云,曹晖,汪明,等.181例胃肠间质瘤的临床病理及预后分析[J].中华胃肠外科杂志,2009,12(2):150 [3]Grignol VP, Termuhlen PM. Gastrointestinal stromal tumor surgery and adjuvant therapy[J].Surg Clin North Am,2011,91(5):1079 [4]张谢夫,刘涛,赵春临,等.胃肠道间质瘤组织中Ki67、细胞周期素D1和细胞间黏附分子1的表达[J].郑州大学学报:医学版,2008,43(3):549 [5]Chang H, Schimmer AD. Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy[J].Mol Cancer Ther,2007,6(1):24 [6]纪长伟,邹继华,杜金荣,等.胃肠间质瘤中Ki67、血管内皮细胞生长因子表达及其与微血管密度和细胞增殖的关系[J].实用医学杂志,2007,23(19):3001 [7]Stacey DW. Three observations that have changed our understanding of cyclin D1 and p27 in cell cycle control[J].Genes Cancer,2010,1(12):1189 [8]Liu Z, Li L, Yang Z,et al. Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma[J].BMC Cancer,2010,10:270

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备注/Memo

备注/Memo:
#通讯作者,男,1957年3月生,教授,研究方向:胃肠道肿瘤的基础与临床, Email:zhangxiefu@medmail.com.cn
更新日期/Last Update: 1900-01-01