[1]赵丽辉)△,张一折),韩德明),等.缬草醇提物和水提物萃取组分对小鼠的抗抑郁作用*[J].郑州大学学报(医学版),2012,(01):47.
 ZHAO Lihui,ZHANG Yizhe,HAN Deming,et al.Antidepressive effects of Valeriana officinalis L. ethanolextraction and waterextraction components on mice[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(01):47.
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缬草醇提物和水提物萃取组分对小鼠的抗抑郁作用*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年01期
页码:
47
栏目:
论著
出版日期:
2012-01-20

文章信息/Info

Title:
Antidepressive effects of Valeriana officinalis L. ethanolextraction and waterextraction components on mice
作者:
赵丽辉1)张一折2)韩德明1)陈玉娟1)周丽云3)
1)长春理工大学生命科学技术学院 长春130022 2)郑州大学生物工程系 郑州450001 3)长春市中心医院血液科 长春 130051
Author(s):
ZHAO Lihui1)ZHANG Yizhe2)HAN Deming1)CHEN Yujuan1)ZHOU Liyun3)
1)School of life Science and Technology, Changchun University of Science and Technology, Changchun 130022 2)Department of Bioengineering, Zhengzhou University, Zhengzhou 450001 3)Department of Hematology,Changchun Center Hospital,Changchun 130051
关键词:
缬草抗抑郁活性组分萃取小鼠
Keywords:
Valeriana officinalis L.antidepressiveactive componentextractionmouse
分类号:
R965.1
摘要:
目的:观察缬草醇提物和水提物萃取组分的抗抑郁作用。方法:100只小鼠随机分为10组,每组10只。阴性对照组给予生理盐水20 mL/kg, 阳性对照组给予安乐片20 mg/kg,缬草醇提物Ⅰ、Ⅱ、Ⅲ、Ⅳ组分别给予缬草醇提物水相、氯仿相、乙酸乙酯相和正丁醇相(200、5、10和25 mg/kg),缬草水提物Ⅰ、Ⅱ、Ⅲ、Ⅳ组分别给予缬草水提物水相、氯仿相、乙酸乙酯相和正丁醇相(200、5、10和25 mg/kg),灌胃给药,连续10 d。给药第10天,用光电计数法测5 min内小鼠自主活动;给药第11天,记录5 min内小鼠强迫游泳不动时间;给药第12天,记录6 min内小鼠悬尾不动时间。结果:10组小鼠自主活动时间相比差异无统计学意义(F=1.418,P=0.260),强迫游泳及悬尾不动时间相比差异有统计学意义(F=99.670和106.564,P<0.001),且醇提物Ⅲ、Ⅳ组和水提物Ⅲ、Ⅳ组强迫游泳及悬尾不动时间均较阴性对照组缩短(P<0.05)。结论:缬草醇提物及缬草水提物的乙酸乙酯相和正丁醇相均有不同程度的抗抑郁作用。
Abstract:
Aim:To observe antidepressive effects of the ethanolextraction and waterextraction components of Valeriana officinalis L. on mice.Methods:A total of 100 mice were allocated into 10 groups, 10 mice in each group. The negative control group was given normal saline at 20 mL/kg, the positive control group was given Anle tablets at 20 mg/kg,the valerian ethanolextraction componentsⅠ,Ⅱ,Ⅲ, and Ⅳ groups were given valerian ethanolextraction components in water, chloroform phase, ethyl acetate phase and nbuoh extraction phase at 200,5,10, and 25 mg/kg, and the valerian waterextraction componentsⅠ,Ⅱ,Ⅲ, and Ⅳ groups were given valerian waterextraction components in water, chloroform phase, ethyl acetate and nbuoh extraction phase at 200,5,10, and 25 mg/kg. All the groups were administered by gavage for 10 days. On the 10th day, the photoelectric counting method was used to record the independent activities of mice within 5 min;on the 11th day,the forced swimming time of mice within 5 min was recorded;on the 12th day, the tail suspension fixed time within 6 min was recorded.Results:There was no statistical differences for 10 groups in independent activities time(F=1.418,P=0.260),but there were statistical differences in the forced swimming time and tail suspension fixed time(F=99.670 and 106.564,P<0.001),and compared with the negative control group, the forcedswimming time and tail suspension fixed time of ethanolextraction components Ⅲ and Ⅳ groups and water extraction components Ⅲ and Ⅳ groups were shorter(P<0.05).Conclusion:Ethyl acetate and nbuoh extraction phases of valerian ethanolextraction components and water extraction components have antidepressive effects.

参考文献/References:

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备注/Memo

备注/Memo:
*吉林省科技发展计划基金资助项目2007090202 doi:10.3969/j.issn.16716825.2012.01.015 △女,1966年7月生,博士,教授,研究方向:分子生物学,Email:zhaolihui2000@yahoo.com.cn
更新日期/Last Update: 1900-01-01