[1]孟庆泽),乔保平)#,宫璀璀),等.肾透明细胞癌组织中T淋巴瘤侵袭转移诱导因子1的表达[J].郑州大学学报(医学版),2012,(01):66.
 MENG Qingze,QIAO Baoping,GONG Cuicui,et al.Expression of Tiam1 in renal clear carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(01):66.
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肾透明细胞癌组织中T淋巴瘤侵袭转移诱导因子1的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年01期
页码:
66
栏目:
论著
出版日期:
2012-01-20

文章信息/Info

Title:
Expression of Tiam1 in renal clear carcinoma tissue
作者:
孟庆泽12)乔保平1)#宫璀璀3)刘德海2)张喜卿4)
1)郑州大学第一附属医院泌尿外科 郑州 450052 2)中国人民解放军第153中心医院泌尿外科 郑州 450042 3)中国人民解放军第153中心医院中心实验室 郑州 450042 4)中国人民解放军第153中心医院病理学实验室 郑州 450042
Author(s):
MENG Qingze12)QIAO Baoping1)GONG Cuicui3) LIU Dehai2)ZHANG Xiqing4)
1)Department of Urology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Urology, the 153th Hospital of Chinese PLA,Zhengzhou 450042 3)Laboratory Center, the 153th Hospital of Chinese PLA,Zhengzhou 450042 4)Department of Pathology, the 153th Hospital of Chinese PLA,Zhengzhou 450042
关键词:
T淋巴瘤侵袭转移诱导因子1肾透明细胞癌预后
Keywords:
T lymphoma invasion and metastasis inducing factor 1renal clear carcinomaprognosis
分类号:
R737.1
摘要:
目的:探讨T 淋巴瘤侵袭转移诱导因子1(Tiam1)表达与肾透明细胞癌发生、发展和转移的关系。方法:应用免疫组化及原位杂交方法检测10例正常肾组织及68例肾透明细胞癌组织中Tiam1 蛋白及mRNA的表达。结果:68例肾透明细胞癌组织中Tiam1蛋白及mRNA的阳性表达率分别为63.2%(43/68)、54.4%(37/68),10例正常肾组织中Tiam1蛋白及mRNA表达均为阴性,二者相比差异有统计学意义(P蛋白<0.001;PmRNA=0.001)。Tiam1蛋白及mRNA的表达与肿瘤的临床分期(χ2蛋白=15.308,P<0.001;χ2mRNA=10.329,P=0.001)、淋巴结转移(χ2蛋白=5.620,P=0.018;χ2mRNA=9.379,P=0.002)及远处转移(χ2蛋白=6.654,P=0.010;χ2mRNA=4.148,P=0.042)有关,而与肿瘤大小无关(χ2蛋白=0.651,P=0.420;χ2mRNA=0.005,P=0.941)。结论:Tiam1对判断肾透明细胞癌的侵袭转移和预后有重要意义。
Abstract:
Aim:To study the expression of T lymphoma invasion and metastasis inducing factor 1(Tiam1) in renal clear carcinoma,and its significance.Methods:The expressions of Tiam1 protein and Tiam1 mRNA in 10 normal renal cases and 68 renal carcinoma cases were detected by immunohistochemical and in situ hybridization.Results:The expressions of Tiam1 protein and mRNA in 10 normal renal tissue were negative.The positive rates of Tiam1 protein and mRNA expression in renal clear carcinoma tissue were 63.2%(43/68)and 54.4%(37/68),and there was statistical significance (Pprotein<0.001;PmRNA=0.001),which were related with clinical stages(χ2protein=15.308,P<0.001;χ2mRNA=10.329,P=0.001),lymph node metastasis(χ2protein=5.620,P=0.018;χ2mRNA=9.379,P=0.002) and distant metastasis(χ2protein=6.654,P=0.010;χ2mRNA=4.148,P=0.042). But not related with tumor size(χ2protein=0.651,P=0.420;χ2mRNA=0.005,P=0.941).Conclusion:Detection of Tiam1 may help to predict the prognosis of renal clear carcinoma.

参考文献/References:

[1]Habets GG,Scholts EH,Zuydgeeal D,et al.Identification of an invasioninducing gene,Tiam1,that encodes a protein with homology to GDPGTP exchangers for Rholike proteins[J].Cell,1994,77(4):537 [2]陈清江,杨丽. 肾癌组织中Tiam1 与KISS1蛋白的表达[J].郑州大学学报:医学版,2009,44(5):1026 [3]Stebel A, Brachetti C, Kunkel M, et al. Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1[J].Oncol Rep,2009,21(1):217 [4]Qi Y, Huang B, Yu L, et al. Prognostic value of Tiam1 and Rac1 overexpression in nasopharyngeal carcinoma[J].ORL J Otorhinolaryngol Relat Spec,2009,71(3):163 [5]Ding Y, Chen B, Wang S, et al. Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients[J].Int J Cancer,2009,124(3):653 [6]许良中,杨文涛.免疫组织化学反应结果的判断标准[J]. 中国癌症杂志,1996,6(4):229 [7]Smirnova T,Zhou ZN,Flinn RJ,et al.Phosphositide 3kinase signaling is critical for ErbB3driven breast cancer cell motility and metastasis[J].Oncogene,2011, doi: 1038/onc.2011.275[Epub ahead of print] [8]Elias BC,Bhattacharya S, Ray RM, et al. Polyaminedependent activation of Rac1 is stimulated by focal adhesionmediated Tiam1 activation[J].Cell Adh Migr,2010,4(3):419 [9]Murakami M, Iwaashita S,Yamaguchi S,et al.Role of nm23 in the regulation of cell shape and migration via Rho family GTPase signals[J].Mol Cell Biochem,2009,329(1/2):175 [10]Kerr BA, Otani T, Koyama E, et al. Small GTPase protein Rac1 is activated with maturation and regulates cell morphology and function in chondrocytes[J].Exp Cell Res,2008,314(6):1301

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备注/Memo

备注/Memo:
doi:10.3969/j.issn.16716825.2012.01.021 #通讯作者,男,1964年7月生,博士,教授,研究方向:泌尿系肿瘤,Email:zhangyaling@zzu.edu.cn
更新日期/Last Update: 1900-01-01