[1]王敏杰,邓克红,李元昆,等.宫颈癌组织中Skp2和有丝分裂前期检查点蛋白的表达[J].郑州大学学报(医学版),2012,(01):69.
 WANG Minjie,DENG Kehong,LI Yuankun,et al.Expressions of Skp2 and Chfr proteins in cervical cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(01):69.
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宫颈癌组织中Skp2和有丝分裂前期检查点蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年01期
页码:
69
栏目:
论著
出版日期:
2012-01-20

文章信息/Info

Title:
Expressions of Skp2 and Chfr proteins in cervical cancer tissue
作者:
王敏杰邓克红李元昆鲁笑钦侯瑞杰崔金全#
郑州大学第二附属医院妇产科 郑州 450014
Author(s):
WANG MinjieDENG KehongLI YuankunLU XiaoqinHOU RuijieCUI Jinquan
Department of Gynecology and Obstetrics,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014
关键词:
宫颈癌S期激酶相关蛋白2有丝分裂前期检查点
Keywords:
cervical cancerSphase kinaseassociated protein 2checkpoint with FHA and ring finger
分类号:
R711.7
摘要:
目的:探讨宫颈癌组织中S期激酶相关蛋白2(Skp2)及有丝分裂前期检查点(Chfr)蛋白的表达及其与宫颈癌临床病理特征的关系。方法:采用免疫组织化学SP法检测60例宫颈癌组织、30例宫颈上皮内瘤变(CIN)组织及30例正常宫颈组织中Skp2和Chfr蛋白的表达。结果:宫颈癌、CIN 和正常宫颈组织中Skp2的阳性表达率分别为63.3%、30.0%和6.7%,而Chfr的阳性表达率分别为48.3%、73.3%和90.0%,组间差异均有统计学意义(χ2=28.525和16.484,P<0.001)。Skp2和Chfr蛋白的表达与宫颈癌的分化程度(χ2=14.713和20.356,P<0.001)及淋巴结转移(χ2= 6.854和8.477,P=0.009和0.004)有关,而与肿瘤大小、临床分期无关。宫颈癌组织中Skp2与Chfr蛋白的表达呈负关联(rP=0.501,P<0.001)。结论:Skp2和Chfr蛋白的表达与宫颈癌的发生发展有密切的关系。
Abstract:
Aim:To explore the expressions of Sphase kinaseassociated protein 2(Skp2) and checkpoint with FHA and ring finger(Chfr) proteins in cervical cancer as well as their relationships with clinical characteristics of cervical cancer.Methods:Skp2 and Chfr were examined with immunohistochemical technique in the specimens from 60 cases of cervical cancer,30 cases of cervical intraepithelial neoplasia(CIN) and 30 cases of normal cervical tissue.Results:The positive expression rate of Skp2 protein was 63.3% in cervical cancer, 30.0% in CIN,and 6.7% in normal cervix, while the positive expression rate of Chfr was 48.3% in cervical cancer,73.3% in CIN and 90.0% in normal cervix,there were obvious differences(χ2=28.525 and 16.484,P<0.001).The expressions of Skp2 and Chfr proteins were related with differentiation of tumor cells (χ2=14.713 and 20.356,P<0.001)and lymph node metastasis(χ2=6.854 and 8.477,P=0.009 and 0.004).The expression of Skp2 protein in cervical cancer was negatively associated to Chfr (rP=0.501,P<0.001).Conclusion:Skp2 and Chfr may play an important role in the development of cervical cancer.

参考文献/References:

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备注/Memo

备注/Memo:
doi:10.3969/j.issn.16716825.2012.01.022 #通讯作者,女,1962年10月生,博士,主任医师,教授,研究方向:妇科肿瘤,Email:jinquan_cui@yahoo.com.cn
更新日期/Last Update: 1900-01-01