[1]王东伟△,刘敏.大剂量瑞舒伐他汀对冠脉支架植入患者血脂、hsCRP水平及急性冠脉事件发生的影响[J].郑州大学学报(医学版),2012,(01):72.
 WANG Dongwei,LIU Min.Effect of rosuvastatin on newly coronary events,plasma lipid and hsCRP level after coronary stenting[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(01):72.
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大剂量瑞舒伐他汀对冠脉支架植入患者血脂、hsCRP水平及急性冠脉事件发生的影响
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年01期
页码:
72
栏目:
论著
出版日期:
2012-01-20

文章信息/Info

Title:
Effect of rosuvastatin on newly coronary events,plasma lipid and hsCRP level after coronary stenting
作者:
王东伟刘敏
郑州市中心医院心内一科 郑州450007
Author(s):
WANG DongweiLIU Min
Department of Cardiology,the Central Hospital of Zhengzhou,Zhengzhou 450007
关键词:
瑞舒伐他汀冠脉介入治疗急性冠脉事件血脂高敏C反应蛋白
Keywords:
rosuvastatincoronary stentnewly coronary eventplasma lipidhigh sensitive Creactive protein
分类号:
R543.3
摘要:
目的:观察大剂量瑞舒伐他汀对冠脉支架植入患者血脂、高敏C反应蛋白(hsCRP)及急性冠脉事件发生的影响。方法:108例急性冠脉综合征冠脉支架植入患者,分别于术前24 h开始应用瑞舒伐他汀20 mg/d(A组,55例)和10 mg/d(B组,53例)至术后1个月。2组常规用药一致。测定用药前后血脂、hsCRP水平,记录术后1个月内急性心脏事件发生率。结果:A组血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)和hsCRP水平的降低幅度大于B组(t=2.294,2.933,5.545,P<0.05)。2组患者急性冠脉事件总发生率差异无统计学意义(χ2=2.105,P=0.147)。结论:大剂量瑞舒伐他汀可更有效控制冠脉支架植入患者术后的炎症反应和血脂水平。
Abstract:
Aim:To investigate the effect of rosuvastatin on the newly major adverse events, plasma lipid and high sensitive Creactive protein (hsCRP) level after coronary stenting in patients with acute coronary syndrome(ACS).Methods:A total of 108 ACS patients after successful stems implantation were divided into two groups.Group A(n=55) and group B(n=53) were given 20 mg/d and 10 mg/d rosuvastatin from 24 h before the implantation to one month after the implantation respectively.The levels of hsCRP and plasma lipid were determined,and the incidence of newly coronary events was recorded.Results:The decreasing amplitude of TC,LDLC and hsCRP in group A was higher than those of group B (t=2.294,2.933,5.545,P<0.05). The newly coronary events incidence had no significant difference between the two groups(χ2=2.105,P=0.147).Conclusion:Highdose rosuvastatin can more effectively control plasma lipid level and inflammatory reaction of ASC patients after coronary stenting.

参考文献/References:

[1]Tousoulis D,Antoniades C,Katsi V, et al.The impact of early administration of lowdose atorvastatin treatment on inflammatory process in patients with unstable angina and low cholesterol level[J]. Int J Cardiol,2006,109(1):48 [2]Wenger NK, Lcwis SJ,Welty FK, et al. Beneficial effects of aggressive lowdensity lipoprotein cholesterol lowering in woman with stable coronary heart disease in the Treating to New Targets(TNT) Study[J]. Heart,2008,94( 4):434 [3]Ross R. Atheroclerosis:an inflammatory disease[J]. N Engl J Med,1999,340(2):115 [4]瑞舒伐他汀中国注册临床研究协作组.瑞舒伐他汀治疗中国高胆固醇血症患者疗效和安全性的随机双盲多中心对照研究[J].中华心血管病杂志,2007,35(3):207 [5]Ridker PM,Danielson E, Fonseca FA,et al.Rosuvastatin to prevent vascular events in men and women with elevated Creactive protein[J].N Engl J Med,2008,359(21):2195 [6]高歌,吕安林,贾国良,等.PTCA支架后冠脉再狭窄全身影响因素的研究[J].中国综合临床,2000,16(7):481

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备注/Memo

备注/Memo:
doi:10.3969/j.issn.16716825.2012.01.023 △男,1976年11月生,硕士,主治医师,研究方向:冠心病的介入治疗,Email:dongwei1129@126.com
更新日期/Last Update: 1900-01-01