[1]白银亮,田新慧,毕跃峰,等.野菊花水提液对豚鼠离体回肠收缩的影响及抑菌作用观察[J].郑州大学学报(医学版),2012,(01):85.
 BAI Yinliang,TIAN Xinhui,BI Yuefeng,et al.Effects of Flos chrysanthemum indicum on the bacterial pathogens and the muscular tension of the isolated ileum of guinea pigs[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(01):85.
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野菊花水提液对豚鼠离体回肠收缩的影响及抑菌作用观察
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年01期
页码:
85
栏目:
论著
出版日期:
2012-01-20

文章信息/Info

Title:
Effects of Flos chrysanthemum indicum on the bacterial pathogens and the muscular tension of the isolated ileum of guinea pigs
作者:
白银亮田新慧毕跃峰王盼张旗#
郑州大学药学院 郑州 450001
Author(s):
BAI YinliangTIAN XinhuiBI YuefengWANG PanZHANG Qi
School of Pharmaceutical Sciences, Zhengzhou University,Zhengzhou 450001
关键词:
野菊花豚鼠离体回肠乙酰胆碱组胺抑菌作用
Keywords:
Flos chrysanthemum indicum guinea pigisolated ileumacetyl cholinediphenhydramineantibacteria
分类号:
R282.710.5
摘要:
目的:观察野菊花水提液对豚鼠离体回肠收缩的影响及其抑菌作用。方法:将豚鼠离体回肠标本悬吊于麦氏浴槽中,测量并记录给药前后离体回肠张力,计算张力变化百分率。采用二倍体积连续稀释法考察野菊花水提液的抗菌效果。结果:野菊花水提液对豚鼠离体回肠收缩有明显的抑制作用(F=11.088,P<0.001),并剂量依赖性地抑制乙酰胆碱及组胺引起的豚鼠回肠收缩(F=13.881、19.305,P均<0.001)。野菊花水提液对金黄色葡萄球菌、大肠杆菌、绿脓假单胞菌和枯草芽孢菌均具有相对较好的抑菌效果,其中对金黄色葡萄球菌的抑菌效果最好,最小抑菌质量浓度为125 g/L。结论:野菊花水提液对豚鼠离体回肠具有直接的舒张作用,能够拮抗乙酰胆碱及组胺引起的豚鼠回肠收缩,同时具有体外抑菌作用。
Abstract:
Aim:To investigate the antibacterial effects of water extract of Flos chrysanthemum indicum and its effects on muscular tension of the isolated ileum of guinea pigs.Methods:The isolated guinea pig ileum in the organbath was used to measure the contractive tension of smooth muscle before and after administration of drug. Double dilution method was used to observe the antibacterial effect of water extract of Flos chrysanthemum indicum.Results:Water extract of Flos chrysanthemum indicum inhibited dosedependently the contraction of normal guinea pig ileum(F=11.088,P<0.001) and that induced by acetyl choline and diphenhydramine(F=13.881 and 19.305,P<0.001). It also had antibacterial effects on Escherichia coli,Pseudomonas aeruginosa,Bacillus subtilis,and especially on Staphylococcus aureus with a lowest antibacterial dosage of 125 g/L.Conclusion:Water extract of Flos chrysanthemum indicum relaxes the smooth muscle of ileum of guinea pigs,and can effectively inhibit the growth of bacteria in vitro.

参考文献/References:

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备注/Memo

备注/Memo:
doi:10.3969/j.issn.16716825.2012.01.027 #通讯作者,男,1976年7月生,博士,教授,研究方向:生化药理与神经药理学,Email:zhangqipku@hotmail.com
更新日期/Last Update: 1900-01-01