[1]刘天舟)△,张琳),王庆芳).非小细胞肺癌患者血清CA153、CA242及CYFRA211水平测定[J].郑州大学学报(医学版),2012,(01):113.
 LIU Tianzhou,ZHANG Lin,WANG Qingfang.Determination of CA153,CA242 and CYFRA211 in serum of patients with nonsmall cell lung cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(01):113.
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非小细胞肺癌患者血清CA153、CA242及CYFRA211水平测定
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年01期
页码:
113
栏目:
应用研究
出版日期:
2012-01-20

文章信息/Info

Title:
Determination of CA153,CA242 and CYFRA211 in serum of patients with nonsmall cell lung cancer
作者:
刘天舟1)张琳2)王庆芳1)
1)郑州大学第一附属医院检验科 郑州 450052 2)郑州大学第一附属医院血液科实验室 郑州 450052
Author(s):
LIU Tianzhou1)ZHANG Lin2)WANG Qingfang1)
1)Clinical Laboratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Hematology Laboratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
非小细胞肺癌糖类抗原153糖类抗原242细胞角蛋白19片段抗原
Keywords:
nonsmall cell lung cancercarbohydrate antigen 153carbohydrate antigen 242cytokeratin 19 fragment
分类号:
R734.2
摘要:
目的:探讨糖类抗原153(CA153)、糖类抗原242(CA242)和细胞角蛋白19片段抗原(CYFRA211)在非小细胞肺癌(NSCLC)患者血清中的表达及意义。 方法:分别采用Roche电化学发光法和酶联免疫吸附法(ELISA)检测49例NSCLC患者(手术前及手术后2 h)和49例健康体检者血清CA153、CA242和CYFRA211水平。结果:NSCLC患者术前血清CA153、CA242和CYFRA211水平均高于对照组(t=24.108、16.208和13.489,P<0.001);与Ⅰ、Ⅱ期相比,TNMⅢ期患者术前血清CA153、CA242和CYFRA211水平升高(t=4.678、3.541和3.045,P<0.001);NSCLC患者术后血清CA153、CA242和CYFRA211水平较术前降低(t=3.362、2.835和2.984,P<0.05)。结论:血清中CA153、CA242和CYFRA211联合检测可能成为NSCLC的早期诊断指标。
Abstract:
Aim:To investigate the serum levels of carbohydrate antigen 153(CA153), carbohydrate antigen 242 (CA242) and cytokeratin 19 fragment (CYFRA211) in patients with nonsmall cell lung carcinoma(NSCLC).Methods:Roche electrochemiluminescence and ELISA were used to determine serum CA153, CA242 and CYFRA211 levels in 49 cases of NSCLC(preand postoperative 2 h) and 49 healthy controls.Results:The serum CA153, CA242 and CYFRA211 levels in NSCLC preoperative patients were higher than those of the control(t=24.108,16.208 and 13.489,P<0.001).The serum CA153, CA242 and CYFRA211 levels in NSCLC TNM stageⅠ,Ⅱpatients were higher than those in NSCLC TNM stage Ⅲpatients (t=4.678,3.541 and 3.045,P<0.001).The serum CA153, CA242 and CYFRA211 levels in NSCLC patients preoperetror were higher than post operation(t=3.362,2.835 and 2.984,P<0.05).Conclusion: Combined detection of serum CA153, CA242 and CYFRA211 levels may be useful for early diagnosis of NSCLC.

参考文献/References:

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备注/Memo

备注/Memo:
doi:10.3969/j.issn.16716825.2012.01.037 △男,1972年1月生,本科,主管技师,研究方向:肿瘤标志物和临床应用,Email:Ltz_888@163.com
更新日期/Last Update: 1900-01-01