[1]尤超,温洪涛#,关冰.食管鳞状细胞癌组织中LRIG3和EGFR蛋白的表达[J].郑州大学学报(医学版),2012,(02):147.
 YOU Chao,WEN Hongtao,GUAN Bing.Expressions of LRIG3 and EGFR proteins in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(02):147.
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食管鳞状细胞癌组织中LRIG3和EGFR蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年02期
页码:
147
栏目:
食管癌研究
出版日期:
2012-03-20

文章信息/Info

Title:
Expressions of LRIG3 and EGFR proteins in esophageal squamous cell carcinoma tissue
作者:
尤超温洪涛#关冰
郑州大学第一附属医院消化内科 郑州 450052
Author(s):
YOU ChaoWEN HongtaoGUAN Bing
Department of Gastroenterology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
富含亮氨酸重复序列免疫球蛋白样蛋白3表皮生长因子受体食管鳞状细胞癌
Keywords:
leucinerich repeats and immunoglobinlike domains 3epidermal growth factor receptoresophagealsquamous cell carcinoma
分类号:
R735.1
摘要:
目的:探讨LRIG3和EGFR蛋白在食管鳞状细胞癌中的表达及其意义。方法:采用免疫组织化学SP法检测60例食管鳞状细胞癌、60例食管正常组织中LRIG3及EGFR的表达水平。结果:LRIG3蛋白在食管鳞状细胞癌组织中的阳性表达率低于食管正常组织(χ2=60.480,P<0.001),EGFR蛋白在食管鳞状细胞癌组织中的阳性表达率高于食管正常组织(χ2=32.976,P<0.05)。LRIG3和EGFR的表达与食管鳞状细胞癌的分化程度、淋巴结转移、肿瘤分期有关(χ2=3.939和4.318、4.374和5.910、5.293和5.884,P<0.05),与性别、年龄无关。LRIG3和EGFR蛋白在食管鳞状细胞癌组织中的表达呈负关联(rP=0.264,P=0.034)。结论:LRIG3表达下降和EGFR表达升高可能在食管鳞状细胞癌的发生发展中起重要作用。
Abstract:
Aim:To investigate the expressions of leucinerich repeats and immunoglobinlike domains 3(LRIG3) and epidermal growth factor receptor(EGFR) proteins in esophageal squamous cell carcinoma(ESCC) tissue.Methods:Immunohistochemical SP method was performed to detect the expressions of LRIG3 and EGFR in 60 cases of ESCC and 60 cases of normal esophageal tissues.Results: The positive expression rate of LRIG3 in normal esophageal tissues was significantly higher than that in ESCC(χ2=60.480,P<0.001).The positive expression rate of EGFR in ESCC was higher than that in the normal esophageal tissue(χ2=32.976,P<0.05),and they were significantly associated with tumor differentiation grade, lymph node metastasis,and clinical stage(χ2=3.939 and 4.318,4.374 and 5.910,5.293 and 5.884,P<0.05). There was a significant negative relation between the expression of LRIG3 and EGFR in ESCC(rP=0.264,P=0.034).Conclusion: The upregulated expression of LRIG3 and the downregulated expression of EGFR may play important roles in the development of ESCC.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1968年2月生,博士,教授,研究方向:消化道肿瘤,Email:Wenhongtao68@163.com
更新日期/Last Update: 1900-01-01