[1]张秋实),张振香)#,杨亚平),等.马铃薯对甘露醇诱导静脉炎模型兔血清IL6水平及局部VEGF表达的影响*[J].郑州大学学报(医学版),2012,(02):175.
 ZHANG Qiushi),ZHANG Zhenxiang),YANG Yaping),et al.Effect of potato external application on serum IL6 level and VEGF expression in local tissue of rabbit with phlebitis induced by mannitol[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(02):175.
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马铃薯对甘露醇诱导静脉炎模型兔血清IL6水平及局部VEGF表达的影响*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年02期
页码:
175
栏目:
论著
出版日期:
2012-03-20

文章信息/Info

Title:
Effect of potato external application on serum IL6 level and VEGF expression in local tissue of rabbit with phlebitis induced by mannitol
作者:
张秋实1)张振香1)#杨亚平1)林蓓蕾1)高峰2)张亚奇1)
1)郑州大学护理学院 郑州 450001 2)河南省医药科学研究院 郑州 450052
Author(s):
ZHANG Qiushi1)ZHANG Zhenxiang1)YANG Yaping1)LIN Beilei1)GAO Feng2)ZHANG Yaqi1)
1)Nursing College,Zhengzhou University,Zhengzhou 450001 2)Henan Provincial Medical Science Institute,Zhengzhou 450052
关键词:
IL6VEGF马铃薯甘露醇静脉炎
Keywords:
IL6VEGFpotatomannitolphlebitisrabbit
分类号:
R471
摘要:
目的:探讨马铃薯贴敷对甘露醇所致静脉炎模型兔血清IL6水平和局部组织中VEGF表达的影响。方法:将25只日本大耳白兔随机分为5组:生理盐水组、模型组、硫酸镁组、马铃薯片贴敷组和马铃薯泥贴敷组,每组5只。后4组静脉给予体积分数20%甘露醇建静脉炎模型。末次贴敷后,取静脉穿刺点周围耳廓组织,采用免疫组化SABC法检测VEGF的表达;采血,采用双抗体夹心ABCELISA法检测血清IL6水平。结果:5组VEGF和IL6水平差异均有统计学意义(F=37.307,50.662,P<0.001)。模型组两指标水平明显高于生理盐水组,硫酸镁组、马铃薯片贴敷组和马铃薯泥贴敷组两指标水平较模型组降低(P<0.05),其中马铃薯泥贴敷组效果更明显,但这3组两指标水平仍高于生理盐水组(P<0.05)。结论:马铃薯贴敷可有效防治甘露醇所致的静脉炎;马铃薯泥贴敷效果优于马铃薯片。
Abstract:
Aim:To observe the effect of potato external applying on phlebitis caused by mannitol in rabbits.Methods:A total of 25 healthy largeeared Japanese rabbits were randomly divided into five groups:negative group,model group,magnesium sulfate group,potato slice and potato paste group.The expression of VEGF in local tissue and serum IL6 were detected by immunohistochemical SABC method and ABCELISA,respectively.Results:There were significant differences in serum level of IL6 and the expression of VEGF among the 5 groups(F=50.662,37.307,P<0.001).They were higher in model group than in negative group(P<0.05),and they were lower in the 3 other groups than in model group,especially in potato paste group(P<0.05),but still higher than those in negative group(P<0.05).Conclusion: Potatoes compress is effective in prevention and treatment of phlebitis induced by mannitol,and the effect of potato paste is superior to potato slice.

参考文献/References:

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备注/Memo

备注/Memo:
*河南省科技厅基础与前沿技术研究计划基金资助项目112300410067;郑州大学2010年研究生科学研究基金资助项目10Y13501Z #通讯作者,女,1961年9月生,教授,研究方向:内科护理,Email:qiutiandeguozi@126.com
更新日期/Last Update: 1900-01-01