[1]王大伟,王喜梅#,刘林嶓,等.病理性瘢痕组织中Livin和Smac的表达[J].郑州大学学报(医学版),2012,(02):209.
 WANG Dawei,WANG Ximei,LIU Linbo,et al.Expressions of Livin and Smac in pathologic scar tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(02):209.
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病理性瘢痕组织中Livin和Smac的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年02期
页码:
209
栏目:
论著
出版日期:
2012-03-20

文章信息/Info

Title:
Expressions of Livin and Smac in pathologic scar tissue
作者:
王大伟王喜梅#刘林嶓张娟孙玉峰
郑州大学第一附属医院整形外科 郑州 450052
Author(s):
WANG Dawei WANG Ximei LIU Linbo ZHANG Juan SUN Yufeng
Department of Plastic Surgery, the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
LivinSmac病理性瘢痕凋亡
Keywords:
LivinSmacpathologic scarapoptosis
分类号:
R318
摘要:
目的:检测病理性瘢痕组织中凋亡抑制蛋白Livin和促凋亡因子Smac的表达情况及两者之间的关系。方法:分别采用RTPCR和免疫组织化学方法检测55例病理性瘢痕(25例瘢痕疙瘩、30例增生性瘢痕),24例非病理性瘢痕和20例正常皮肤组织中Livin和Smac mRNA和蛋白的表达。结果:以上4种组织中Livin和Smac mRNA和蛋白的表达差异均有统计学意义(mRNA:F=269.533和95.514,P<0.001;蛋白:χ2=36.611和26.320,P<0.001);瘢痕疙瘩、增生性瘢痕中Livin mRNA的表达水平和蛋白的阳性表达率高于非病理性瘢痕及正常皮肤组织,Smac mRNA的表达水平和蛋白的阳性表达率低于非病理性瘢痕及正常皮肤组织(P<0.05或0.008)。病理性瘢痕组织中Livin和Smac蛋白的表达呈负关联(rP=0.418, P<0.001)。结论:Livin和Smac可能在病理性瘢痕凋亡信号传导网络中起重要的作用。
Abstract:
Aim:To investigate the expressions of Livin and Smac in pathologic scar tissue.Methods:RTPCR and SP immunohistochemical methods were used to detect the mRNA and protein expressions of Livin and Smac in 55 pathologic scar (25 cases of keloid,30 cases of hypertrophic scar),24 cases of nonpathologic scar and 20 cases of normal skin tissue.Results:There were significant differences in the expressions of Livin and Smac mRNA and protein in four kinds of tissue (mRNA:F=269.533 and 95.514,P<0.001;protein:χ2=36.611 and 26.320,P<0.001).Compared with the nonpathologic scar group and normal skin tissue group,the mRNA expression level and protein positive expression rate of Livin in keloid group and hypertrophic scar group were higher,while the mRNA expression level and protein positive expression rate of Smac in keloid group and hypertrophic scar group were lower(P<0.05 or 0.008).There was negative association between Livin and Smac protein expression in pathologic scar (rP=0.418, P<0.001).Conclusion:Livin and Smac might play an important role in the apoptosis pathway of pathologic scar.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,女,1962年1月生,博士,主任医师,教授,研究方向:病理性瘢痕的基础与临床研究,Email:wangximei228@gmail.com
更新日期/Last Update: 1900-01-01