[1]安红伟),卢昌均)#,赵德强).脑白质疏松对脑梗死预后的影响[J].郑州大学学报(医学版),2012,(02):235.
 AN Hongwei),LU Changjun),ZHAO Deqiang).Effect of leukoaraiosis on prognosis of cerebral infarction[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(02):235.
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脑白质疏松对脑梗死预后的影响
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年02期
页码:
235
栏目:
论著
出版日期:
2012-03-20

文章信息/Info

Title:
Effect of leukoaraiosis on prognosis of cerebral infarction
作者:
安红伟1)卢昌均1)#赵德强2)
1)柳州市中医院神经内科 柳州 545001 2)南方医科大学南方医院神经内科 广州 510515
Author(s):
AN Hongwei1)LU Changjun1)ZHAO Deqiang2)
1)Department of Neurology,Liuzhou Traditional Chinese Medicine Hospital,Liuzhou 545001 2)Department of Neurology,Nanfang Hospital,Southern Medical University,Guangzhou 510515
关键词:
脑白质疏松脑梗死预后
Keywords:
leukoaraiosiscerebral infarctionprognosis
分类号:
R743.32
摘要:
目的:探讨脑白质疏松(LA)对脑梗死预后的影响。方法:将在发病48 h内住院的173例急性脑梗死患者按照是否伴有LA分为伴LA组(63例)与单纯脑梗死组(110例),并随访1 a,分别于入院时,治疗后1、6、9个月及1 a时行中国脑卒中临床神经功能缺损程度(CSS)、日常生活能力评定Barthel指数(BI)、简易精神状态量表(MMSE)测评,并统计脑梗死复发率。结果:2组患者随访期内CSS评分、BI、MMSE评分组内效应、组间效应及交互效应差异均有统计学意义。2组入院时及治疗后1个月、3个月时CSS、BI及MMSE评分差异无统计学意义(P>0.05)。治疗后6个月以后脑梗死伴LA组CSS评分高于单纯脑梗死组,BI及MMSE评分低于单纯脑梗死组(P<0.05)。随访1 a,脑梗死伴LA组脑梗死复发时间(10.651±0.037)个月(95%CI为9.926~11.376个月),单纯脑梗死组为(11.464±0.173)个月(95%CI为11.125~11.802个月),脑梗死伴LA组脑梗死复发时间早于单纯脑梗死组(χ2L=4.964,P=0.026)。结论:LA对脑梗死的预后有明显影响,且增加复发风险。
Abstract:
Aim:To study the effect of leukoaraiosis (LA) on prognosis of cerebral infarction.Methods:A total of 173 patients with acute cerebral infarction within 48 h were divided into coLA group(63 cases) and nonLA group(110 cases). The Chinese Stroke Scale (CSS) score, Barthel Index (BI) of daily living assessment,the minimental state examination(MMSE) score and the recurrence were recorded at admission,1,3,6,9 months and 1 a after admission.Results:There were significant differences in CSS,BI and MMSE score between the two groups at different time points(P<0.05).There was no significant difference between the two groups in CSS,BI and MMSE score at admission and 3,6 months after the admission (P>0.05).At 6,9 months and 1 a after the admission,coLA group had higher CSS score, lower BI and MMSE score compared with nonLA group (P<0.05).During oneyear followup, the time of recurrence of cerebral infarction in coLA group was (10.651±0.037) months (95%CI was 9.926~11.376 months),significantly higher than that (11.464±0.173) months (95% CI was 11.125~11.802 months) in nonLA group (χ2L=4.964,P=0.026).Conclusion: LA may increases the recurrence risk of cerebral infarction.

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备注/Memo

备注/Memo:
#通讯作者,男,1963年7月生,博士,副主任医师,研究方向:神经危重病的监护与治疗,Email:lchj477@yahoo.com.cn
更新日期/Last Update: 1900-01-01