[1]关兵峰),崔新征),方华),等.重症肌无力患者胸腺组织中胆碱乙酰转移酶和烟碱型乙酰胆碱受体的表达*[J].郑州大学学报(医学版),2012,(03):299.
 GUAN Bingfeng),CUI Xinzheng),FANG Hua),et al.Expression of and choline acetyltransferase nicotinic acetylcholine receptor in thymus tissue of myasthenia gravis patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(03):299.
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重症肌无力患者胸腺组织中胆碱乙酰转移酶和烟碱型乙酰胆碱受体的表达*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年03期
页码:
299
栏目:
专题研究
出版日期:
2012-05-20

文章信息/Info

Title:
Expression of and choline acetyltransferase nicotinic acetylcholine receptor in thymus tissue of myasthenia gravis patients
作者:
关兵峰12)崔新征12)方华3)张迎娜3) 赵莹3)张清勇12)#高峰3)
1)郑州大学第二附属医院胸外科 郑州 450014 2)郑州大学生物医学工程研究所 郑州 450014 3)郑州大学医药科学研究院免疫学研究室神经免疫实验室 郑州 450052
Author(s):
GUAN Bingfeng12)CUI Xinzheng12)FANG Hua3)ZHANG Yingna3)ZHAO Ying3)ZHANG Qingyong12)GAO Feng3)
4)Lab of Neuroimmunology, Department of Immunology Research,Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 4500525) Department of Microbiology and Immunology,College of Basic Medical Sciences, Zhengzhou University,Zhengzhou 450001
关键词:
重症肌无力胆碱乙酰转移酶烟碱型胆碱能受体胸腺
Keywords:
myasthenia gravischoline acetyltransferasenicotinic acetylcholine receptorthymus
分类号:
R593.2
摘要:
目的:探讨重症肌无力(MG)患者胸腺组织中胆碱乙酰转移酶(CHAT)和烟碱型乙酰胆碱受体(nAChR)的表达。方法:采用免疫组化方法检测胸腺增生(20例)、胸腺瘤(10例)、胸腺萎缩(10例)及10例正常胸腺组织中CHAT和nAChR蛋白的表达情况。结果:不同胸腺组织中CHAT和nAChR蛋白的表达差异有统计学意义(F=16.271,15.083,P<0.001)。与正常胸腺和胸腺萎缩组织相比,胸腺瘤和胸腺增生组织中CHAT蛋白的表达增高(P<0.05);胸腺瘤组织中nAChR蛋白表达低于胸腺增生组织(P<0.05);胸腺萎缩组织中nAChR蛋白的表达也低于正常对照组(P<0.05)。结论:胸腺组织中CHAT和nAChR蛋白表达水平的改变可能是MG的发病机制之一。
Abstract:
Aim:To explore the significance of choline acetyltransferase(CHAT) and nicotinic acetylcholine receptor(nAChR) in the thymus tissue of myasthenia gravis (MG) patients.Methods:Immunohistochemistry was used to compare the protein expression level of CHAT and nAChR in the thymus tissue from MG patients of 3 histological types(20 patients with hyperplasia,10 patients with thymoma,and 10 patients with atrophy) and normal thymus tissue from 10 normal controls.Results:The expression levels of the CHAT and the nAChR protein in thymus tissue from the 4 groups was statistical different(F=16.271,15.083,P<0.001).Compared with the control group and the atrophy group,the expression of CHAT in the thymoma group and the hyperplasia group was higher(P<0.05). The expression of nAChR in the thymoma group was lower than the hyperplasia group(P<0.05).The expression of nAChR in the atrophy group was lower than that in the control group(P<0.05).Conclusion:Changes in expression levels of nAChR and CHAT in thymus of MG patients may be one of the pathogenic mechanisms for MG.

参考文献/References:

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目30570625重症肌无力患者胸腺组织中胆碱乙酰转移酶和烟碱型乙酰胆碱受体的表达* #通讯作者,男,1963年11月生,主任医师,教授,研究方向:重症肌无力的临床医学与发病机制,Email:qyzhang@zzu.edu.cn
更新日期/Last Update: 2012-05-31