[1]侯钰佩),郭阿丽),翟广玉)#,等.槲皮素锗对多种肿瘤细胞增殖的抑制作用*[J].郑州大学学报(医学版),2012,(03):333.
　HOU Yupei),GUO Ali),ZHAI Guangyu),et al.Inhibitive effects of quercetinGe （Ⅳ） complex on proliferation of 4 kinds of tumor cells[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(03):333.
点击复制

槲皮素锗对多种肿瘤细胞增殖的抑制作用*
分享到：

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年03期
页码:
333
栏目:
论著
出版日期:
2012-05-20

文章信息/Info

Title:
Inhibitive effects of quercetinGe （Ⅳ） complex on proliferation of 4 kinds of tumor cells
作者:
侯钰佩1); 郭阿丽1); 翟广玉1)#; 马岩2); 马海英1); 王鹏1); 朱玮3); 渠文涛3)
1)郑州大学护理学院 郑州 4500522）郑州大学附属郑州中心医院 郑州 4500073）郑州大学药学院 郑州 450001
Author(s):
HOU Yupei1); GUO Ali1); ZHAI Guangyu1); MA Yan2); MA Haiying1); WANG Peng1); ZHU Wei3); QU Wentao3)
1)Nursing College,Zhengzhou University, Zhengzhou 4500522)Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 4500073）School of Pharmaceutical Sciences, Zhengzhou University，Zhengzhou 450001
关键词:
槲皮素; 锗; 增殖; Hela; SPCA1; EC9706; PC3
Keywords:
quercetin; Ge; proliferation; Hela; SPCA1; EC9706; PC3
分类号:
R733
摘要:
目的：观察槲皮素锗对多种肿瘤细胞增殖的抑制作用。方法：槲皮素与氧化锗反应生成槲皮素锗，经结构鉴定为目标产物后，分别用0、10、100 μmol/L槲皮素锗处理人子宫颈癌Hela细胞、肺癌SPCA1细胞、人食管癌EC9706细胞和人前列腺癌PC3细胞72 h，采用MTT法检测细胞增殖抑制率。结果：槲皮素锗体外对上述4种细胞增殖均有抑制作用，以高浓度组作用更为明显（P<0.05）。结论：槲皮素锗具有抑制多种肿瘤细胞增殖的作用。
Abstract:
Aim:To observe the inhibitive effects of quercetinGe(Ⅳ) complex on 4 kinds of tumor cells.Methods:The quercetinGe(Ⅳ) complex was prepared and identified.MTT method was used to observe the inhibition effect of 0,10,and 100 μmol/L quercetinGe(Ⅳ) complex on 4 kinds of tumor cells (PC3, Hela, EC9706 and SPCA1) for 72 h.Results: The result showed that the complex exerted notable inhibitory effect on the proliferation of PC3, Hela, EC9706 and SPCA1 cells,especially the highdose group.Conclusion:GuercetinGe (Ⅳ) complex can inhibit the proliferation of mutiple tumor cells.

参考文献/References:

［1］Boots AW,Haenen GR, Bast A. Health effects of quercetin:from antioxidant to nutraceutical［J］. Eur J Pharmacol，2008，585(2/3)：325
[2]Sultana B,Anwar F. Flavones (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants［J］.Food Chem,2008，108：879
[3]Russo M,Spagnuolo C,Tedesco I,et al.The flavonoid quercetin in disease prevention and therapy:facts and fancies［J］.Biochem Pharmacol,2012,83（1）：6
[4]Moskaug JΦ,Carlsen H,Myhrstad M,et al.Molecular imaging of the biological effects of quercetin and quercetinrich foods［J］. Mech Ageing Dev，2004,125（4）：315
[5]Tan J, Zhu LC, Wang BC. From GCrich DNA binding to the repression of survivin gene for quercetin nickel (Ⅱ) complex: implications for cancer therapy［J］.Biometals,2010,23（6）:1075
[6]Zhou J, Wang LF, Wang JY,et al.Antioxidative and antitumour activities of solid quercetin metal(Ⅱ) complexes［J］.Transit Met Chem,2001,26:57
[7]Ferrer EG, Salinas MV, Correa MJ, et al. Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(Ⅳ) complexes［J］.J Biol Inorg Chem,2006,11（6）:791
[8]Torralvo FA,Pereira CF.Recovery of germanium from real fly ash leachates by ionexchange extraction［J］.Miner Eng,2011,24(1）:35

相似文献/References:

[1]李丹),杨冉),曾华金),等.RPHPLC同时测定金钱通淋颗粒中槲皮素、木犀草素及山奈酚的含量[J].郑州大学学报(医学版),2010,(01):145.
　LI Dan),YANG Ran),ZENG Huajin),et al.RPHPLC determination of contents of quercetin，luteolin and kaeampferol in Jinqiantonglin granule[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(03):145.
[2]姚芳芳）,张锐）,傅瑞娟）,等. 槲皮素对高尿酸血症大鼠黄嘌呤氧化酶和腺苷脱氨酶活性的影响[J].郑州大学学报(医学版),2011,(02):248.
　YAO Fangfang,ZHANG Rui,FU Ruijuan,et al. Effects of quercetin on activity of XOD and ADA in hyperuricemic rats[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(03):248.

备注/Memo

备注/Memo:
*郑州大学大学生创新性实验计划项目2009cxsy008 #通讯作者，男，1954年11月生，教授，研究方向：药物化学合成，Email：Zhaiguangyu1@sina.com
更新日期/Last Update: 2012-05-31