[1]王红△.血清胱抑素C和脂蛋白(a)对早期糖尿病肾病的诊断价值[J].郑州大学学报(医学版),2012,(03):390.
 WANG Hong.Diagnostic value of serum cystatin C and lipoprotein(a) for early diabetic nephropathy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(03):390.
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血清胱抑素C和脂蛋白(a)对早期糖尿病肾病的诊断价值
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年03期
页码:
390
栏目:
应用研究
出版日期:
2012-05-20

文章信息/Info

Title:
Diagnostic value of serum cystatin C and lipoprotein(a) for early diabetic nephropathy
作者:
王红
河南省职工医院综合内科 郑州 450002
Author(s):
WANG Hong
Department of Internal Medicine, Zhigong Hospital of Henan Province, Zhengzhou 450002
关键词:
糖尿病肾病 胱抑素C脂蛋白(a)
Keywords:
diabetic nephropathycystatin Clipoprotein(a)
分类号:
R587.2
摘要:
目的:探讨联合检测血清胱抑素C(Cys C)、脂蛋白(a)水平对早期糖尿病肾病(DN)的诊断价值。方法:采用免疫比浊法分别检测60例早期DN患者(DN组)、55例无肾病的糖尿病患者(NDN组)和50 例健康成年人(对照组)血清Cys C和脂蛋白(a)水平,并分析比较单项及联合检测对早期DN的诊断效能。结果:DN组血清Cys C和脂蛋白(a)水平均高于对照组和NDN组(F=5.888,14.026,P均<0.05); 二者诊断DN的灵敏度分别为86.7%和68.3%,特异度分别为95.0%和93.3%,二项指标联合检测灵敏度达91.6%,特异度达91.7%。结论:Cys C与脂蛋白(a)联合检测较单项检测能大大提高检测灵敏度,对于早期DN的诊断有重要意义。
Abstract:
Aim:To explore the diagnostic value of serum cystatin C(Cys C) and lipoprotein(a) for early diabetic nephropathy(DN).Methods:The immune turbidimetry was used to detect serum Cys C and lipoprotein(a) in 60 cases of patients with early DN(DN group),55 patients without nephropathy but with diabetes mellitus(NDN group),and 50 healthy adults(control group).The efficacy of single index or 2 indexes combined in diagnosis of early DN was compared.Results:Serum Cys C and lipoprotein(a) in early DN group were significantly higher than those in the control group and NDN group(F=5.888,14.026,P<0.05).The sensitivity of Cys C and lipoprotein(a) in diagnosis of DN was 86.7% and 68.3%,specificity was 95.0% and 93.3%,which were 91.6% and 91.7% when the 2 indexes combined.Conclusion:Combined detecting serum Cys C and lipoprotein (a) can greatly improve detection sensitivity of early DN.

参考文献/References:

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备注/Memo

备注/Memo:
△女,1968年7月生,本科,副主任医师,研究方向:内分泌,Email:wanghong0930@163.com
更新日期/Last Update: 2012-05-31