[1]刘进忠△,张沛.大鼠口腔鳞状细胞癌组织中EphA2、EphrinA1和Ecadherin的表达[J].郑州大学学报(医学版),2012,(04):485.
 LIU Jinzhong,ZHANG Pei.Expressions of EphA2,EphrinA1 and Ecadherin in oral squamous cell carcinoma tissue of rats[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(04):485.
点击复制

大鼠口腔鳞状细胞癌组织中EphA2、EphrinA1和Ecadherin的表达
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年04期
页码:
485
栏目:
论著
出版日期:
2012-07-20

文章信息/Info

Title:
Expressions of EphA2,EphrinA1 and Ecadherin in oral squamous cell carcinoma tissue of rats
作者:
刘进忠张沛
郑州大学第四附属医院口腔病理科 郑州 450052
Author(s):
LIU Jinzhong ZHANG Pei
Department of Oral Pathology,the Fourth Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
口腔鳞状细胞癌EphA2EphrinA1Ecadherin大鼠
Keywords:
oral squamous cell carcinomaEphA2EphrinA1Ecadherinrat
分类号:
R780.2
摘要:
目的:检测大鼠口腔鳞状细胞癌发生及演变组织中EphA2、EphrinA1和Ecadherin的表达。方法:采用免疫组化SP法检测大鼠腭部的7例正常黏膜、14例上皮单纯性增生黏膜、6例上皮轻度异常增生黏膜、10例上皮中度异常增生黏膜、19例上皮重度异常增生黏膜和14例口腔鳞状细胞癌黏膜组织中EphA2、EphrinA1和Ecadherin的表达。结果:随正常黏膜到口腔鳞状细胞癌的发生演变,EphA2和EphrinA1的表达呈升高的趋势,Ecadherin的表达呈降低的趋势(F=35.903、101.757和65.409,P<0.001)。口腔鳞状细胞癌组织中EphA2与EphrinA1的表达呈正相关(r=0.708,P=0.015),与Ecadherin的表达呈负相关(r=-0.531,P=0.004); EphrinA1与Ecadherin的表达呈负相关(r=-0.596,P<0.001)。结论:EphA2、 EphrinA1和Ecadherin可能共同参与了口腔鳞状细胞癌的发生演变。
Abstract:
Aim:To detect the expressions of EphA2,EphrinA1 and Ecadherin in the carcinogenesis and progression of oral squamous cell carcinoma(OSCC) of rats.Methods:Immunohistochemical SP method was used to detect the expressions of EphA2, EphrinA1 and Ecadherin in 7 cases of normal mucosa,14 cases of epithelial hyperplasia mucosa, 6 cases of mild epithelial dysplasia mucosa,10 cases of moderate epithelial dysplasia mucosa,19 cases of severe epithelial dysplasia mucosa, and 14 cases of OSCC mucosa in the palates of rats.Results:The expressions of EphA2 and EphrinA1 had a tendency of increasing while that of Ecadherin had a tendency of decreasing during the progression from normal mucosa to OSCC mucosa(F=35.903, 101.757 and 65.409, P<0.001).In OSCC tissue, the expressions of EphA2 and EphrinA1 were positively associated(r=0.708,P=0.015); those of EphA2 and Ecadherin were negatively associated(r=-0.531,P=0.004); those of EphrinA1 and Ecadherin were negatively associated(r=-0.596,P<0.001).Conclusion:EphA2, EphrinA1 and Ecadherin may participate in the carcinogenesis and progression of OSCC.

参考文献/References:

[1]Greenlee RT,HillHarmon MB,Murray T,et al.Cancer statistics[J]. CA Cancer J Clin,2001, 51(1):15
[2]邱蔚六. 口腔颌面外科学[M]. 4版. 北京:人民卫生出版社,2000.
[3]Scully C, Bagan J. Oral squamous cell carcinoma overview [J]. Oral Oncology, 2009, 45(4/5):301
[4]史培荣. 口腔鳞状细胞癌组织中STAT3和CyclinD1的表达及意义[D].太原:山西医科大学,2010.
[5]van der Geer P, Hunter T,Lindberg RA. Receptor proteintyrosine kinases and their signal transduction pathways[J]. Annu Rev Cell Biol,1994,10:251
[6]WalkerDaniels J, Hess AR,Hendrix MJ,et al. Differential regulation of EphA2 in normal and malignant cells[J]. Am J Pathol, 2003, 162(4):1037
[7]Byrne RR, Shariat SF,Brown R,et al.Ecadherin immunostaining of bladder transitional cell carcinoma,carcinoma in situ and lymph node metastases with long term followup[J].J Urol,2001,165(5):1473
[8]Abraham S, Knapp DW, Cheng L, et al. Expression of EphA2 and Ephrin A1 in carcinoma of the urinary bladder[J]. Clin Cancer Res, 2006,12(2):353
[9]Coffman KT, Hu M, CarlesKinch K, et al.Differential EphA2 epitope display on normal versus malignant cells[J]. Cancer Res,2003,63(22):7907
[10]Orsulic S,Kemler R.Expression of Eph receptors and ephrins is differentially regulated by Ecadherin[J].J Cell Sci,2000,113(Pt 10):1793

相似文献/References:

[1]张弓,朱长举,宋燕,等.原发性肝细胞癌组织中EphA2和E钙黏素蛋白的表达[J].郑州大学学报(医学版),2010,(01):93.
 ZHANG Gong,ZHU Changju,SONG Yan,et al.Expression of EphA2 and Ecadherin in hepatocellular carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2010,(04):93.
[2]毛兰萍△,尚君兰,祝磊,等.人口腔扁平苔藓及口腔鳞癌组织中P16、Survivin蛋白的表达[J].郑州大学学报(医学版),2009,(05):1014.
 MAO Lanping,SHANG Junlan,ZHU Lei,et al.Expression of P16 and Survivin protein in oral lichen planus and oral squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):1014.
[3]韩丽萍)△,乔玉环),董子明),等.激光捕获显微切割技术检测卵巢癌组织中EphA2受体的表达[J].郑州大学学报(医学版),2009,(02):368.
 HAN Liping),QIAO Yuhuan),DONG Ziming),et al.Expression of EphA2 receptor in ovarian carcinoma assisted by laser capture microdissection[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):368.
[4]高黎)△,王国芳),季旭东),等.口腔黏膜白斑及鳞癌组织中核因子κBp65与PCNA的表达[J].郑州大学学报(医学版),2009,(03):582.
 GAO Li),WANG Guofang),JI Xudong),et al.Expression of NFκB p65 and PCNA during oral leukoplakia carcinogenesis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(04):582.
[5]付莉,刁振琦,刘健峰,等.口腔鳞状细胞癌组织的拉曼光谱观察[J].郑州大学学报(医学版),2011,(05):786.

备注/Memo

备注/Memo:
△男,1967年12月生,博士,副主任医师,研究方向:口腔癌的早期诊断,Email:Liujz@zzu.edu.cn
更新日期/Last Update: 2012-08-14