[1]李向垒),王贵吉)#,裴迎新),等.胃癌组织中F框/WD40域蛋白7和Cyclin E蛋白的表达[J].郑州大学学报(医学版),2012,(04):494.
 LI Xianglei,WANG Guiji,PEI Yingxin,et al.Expressions of FBXW7 and Cyclin E proteins in gastric carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(04):494.
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胃癌组织中F框/WD40域蛋白7和Cyclin E蛋白的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年04期
页码:
494
栏目:
论著
出版日期:
2012-07-20

文章信息/Info

Title:
Expressions of FBXW7 and Cyclin E proteins in gastric carcinoma tissue
作者:
李向垒1)王贵吉1)#裴迎新2)张琪1)王夏飞1)
1)郑州大学第一附属医院肿瘤科 郑州 450052 2)郑州大学公共卫生学院营养与食品卫生学教研室 郑州 450001
Author(s):
LI Xianglei1)WANG Guiji1)PEI Yingxin2)ZHANG Qi1)WANG Xiafei1)
1)Department of Oncology,the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052 2)Department of Nutrition and Food Hygiene,College of Public Health,Zhengzhou University,Zhengzhou 450001
关键词:
F框/WD40域蛋白7Cyclin E蛋白胃癌
Keywords:
Fbox/WD repeatcontaining protein 7Cyclin Egastric carcinoma
分类号:
R735.2
摘要:
目的:研究F框/WD40域蛋白7(FBXW7)和Cyclin E蛋白在胃癌组织中的表达。方法:应用免疫组化SP法检测75例胃癌和25例癌旁正常胃组织中FBXW7和Cyclin E蛋白的表达。结果:胃癌、癌旁正常胃组织中FBXW7 和Cyclin E蛋白阳性表达率差异有统计学意义(χ2=10.606和7.692,P=0.001和0.006)。FBXW7蛋白的表达与胃癌的分化程度(χ2=7.440,P=0.006)、淋巴结转移(χ2=4.688,P=0.030)、TNM分期(χ2=4.601,P=0.032)有关;Cyclin E蛋白的表达与胃癌的浸润深度(χ2=4.902,P=0.027)、淋巴结转移(χ2=4.601,P=0.032)、TNM分期(χ2=4.408,P=0.036)有关。胃癌组织中FBXW7与Cyclin E蛋白的表达呈负关联(rP=-0.459,P<0.001)。结论:FBXW7和Cyclin E可能在胃癌的发生发展中起重要作用。
Abstract:
Aim:To investigate the expressions of Fbox/WD repeatcontaining protein 7(FBXW7) and Cyclin E in gastric carcinoma.Methods:Immunohistochemistry SP method was used to examine the expressions of FBXW7 and Cyclin E proteins in 75 cases of gastric carcinoma and 25 cases of paracarcinoma normal tissues.Results:The positive expression rates of FBXW7 and Cyclin E proteins in gastric carcinoma and paracarcinoma normal tissues had significant differences(χ2=10.606 and 7.692,P=0.001 and 0.006),and the expression of FBXW7 in carcinoma tissue was significantly related with the differentiation degree(χ2= 7.440,P=0.006),lymphatic metastasis (χ2= 4.688,P=0.030) and the clinical stage(χ2= 4.601,P=0.032).The expression of Cyclin E was significantly related with invasion depth(χ2= 4.902,P=0.027),lymphatic metastasis (χ2=4.601,P=0.032) and clinical stage(χ2= 4.408,P=0.036).The expression of FBXW7 was negatively associated with that of Cyclin E(rP=-0.459,P<0.001) in gastric carcinoma tissue.Conclusion:FBXW7 and Cyclin E may play important roles in the development of gastric carcinoma.

参考文献/References:

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备注/Memo

备注/Memo:
#通讯作者,男,1954年6月生,本科,教授,研究方向:消化道肿瘤,Email:pyx@zzu.edu.cn
更新日期/Last Update: 2012-08-14