[1]李留霞)△,吴改英),王宁),等.子痫前期患者胎盘组织中内皮分化基因2的表达[J].郑州大学学报(医学版),2012,(04):497.
 LI Liuxia,WU Gaiying,WANG Ning,et al.Expression of endothelial differentiation gene 2 in placenta of patients with preeclampsia[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(04):497.
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子痫前期患者胎盘组织中内皮分化基因2的表达
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年04期
页码:
497
栏目:
论著
出版日期:
2012-07-20

文章信息/Info

Title:
Expression of endothelial differentiation gene 2 in placenta of patients with preeclampsia
作者:
李留霞1)吴改英1)王宁1)张毅23)郭瑞霞1)张孝艳1)
1)郑州大学第一附属医院妇产科 郑州 450052 2)郑州大学第一附属医院生物细胞治疗中心 郑州 450052 3)郑州大学生物工程系 郑州 450001
Author(s):
LI Liuxia1)WU Gaiying1)WANG Ning1)ZHANG Yi23)GUO Ruixia1)ZHANG Xiaoyan1)
1)Department of Obstetrics and Gynecology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Biological Cells Treatment Center,the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052 3)Department of Bioengineering,Zhengzhou University,Zhengzhou 450001
关键词:
子痫前期胎盘组织内皮分化基因2
Keywords:
preeclampsiaplacental tissueendothelial differentiation gene 2
分类号:
R713.24
摘要:
目的:探讨子痫前期患者胎盘组织中内皮分化基因(Edg)2蛋白和mRNA的表达及意义。方法:应用免疫组化SP和RTPCR方法检测20例正常晚孕妇女、20例子痫前期轻度和20例子痫前期重度患者胎盘组织中Edg2蛋白和mRNA的表达。结果:3组胎盘绒毛滋养和蜕膜细胞中Edg2蛋白以及胎盘组织Edg2 mRNA的表达差异有统计学意义(F/χ2=19.063、19.063和2 232.999,P<0.001),子痫前期轻度和重度组高于正常晚孕组,子痫前期重度组高于子痫前期轻度组。结论:胎盘组织中 Edg2的异常表达可能与子痫前期的发生和发展有关。
Abstract:
Aim:To investigate the protein and mRNA expressions of endothelial differentiation gene(Edg)2 in the placenta of patients with preeclampsia.Methods:Immunohistochemistry SP method and RTPCR were used to detect the protein and mRNA expressions of Edg2 in the placenta of 40 cases of preeclampsia(20 cases of mild preeclampsia and 20 cases of severe preeclampsia) and 20 cases of normal late pregnant women.Results:The expression of Edg2 protein in the trophoblast and decidual cell of placental tissue,and the expression of Edg2 mRNA in placental tissues among the 3 groups had significant differences(F/χ2=19.063,19.063,and 2 232.999,P<0.001),which were higher in mild and severe preeclampsia patients than those in normal later pregnant women,and higher in severe preeclampsia patients than those in mild preeclampsia patients.Conclusion:The abnormal expression of Edg2 may be related with the process of genesis and development of preeclampsia.

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备注/Memo

备注/Memo:
△女,1962年11月生,博士,教授,主任医师,研究方向:妇科肿瘤和围产医学,Email:llxia698@163.com
更新日期/Last Update: 2012-08-14