[1]冯惠民,李廷坤,吕帅国,等.丙泊酚麻醉对肝癌射频消融术患者血清白介素和HSP70水平的影响[J].郑州大学学报(医学版),2012,(04):542.
 FENG Huimin,LI Tingkun,LV Shuaiguo,et al.Effects of propofol anesthesia on serum interleukins and HSP70 levels in patients with liver cancer after radiofrequency ablation[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(04):542.
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丙泊酚麻醉对肝癌射频消融术患者血清白介素和HSP70水平的影响
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年04期
页码:
542
栏目:
应用研究
出版日期:
2012-07-20

文章信息/Info

Title:
Effects of propofol anesthesia on serum interleukins and HSP70 levels in patients with liver cancer after radiofrequency ablation
作者:
冯惠民李廷坤吕帅国冯艳平李长生#
河南省肿瘤医院麻醉科 郑州 450003
Author(s):
FENG HuiminLI TingkunLV ShuaiguoFENG YanpingLI Changsheng
Department of Anesthesiology,Henan Tumor Hospital,Zhengzhou University,Zhengzhou 450003
关键词:
丙泊酚射频消融白细胞介素HSP70肝癌
Keywords:
propofolradiofrequency ablationinterleukinHSP70liver cancer
分类号:
R735.7
摘要:
目的:探讨丙泊酚全身麻醉对肝癌射频消融术患者血清白介素(IL)6、8、10和热休克蛋白70(HSP70)水平的影响。方法:择期行肝癌射频消融术的患者40例,分成2组施术,每组20例。观察组患者在全麻诱导后应用丙泊酚和瑞芬太尼维持麻醉,对照组患者在穿刺部位利多卡因局部阻滞麻醉。术中检测麻醉前、首次穿刺成功时,热封闭针道时,术后1 h、24 h和48 h时的平均血压、心率、脉搏血氧饱和度和体温;采集患者术前,术后1、24和48 h静脉血5 mL,ELISA法测定血清IL6、IL10、IL8及HSP70。结果:2组患者术中和术后体温、血压均升高,但观察组变化幅度小于对照组(体温:F组间=14.568,F时间=291.525,F交互=13.655,P均<0.001;血压:F组间=23.372,F时间=14.007,F交互=25.795,P均<0.001)。2组术后血清IL6、8、10及HSP70水平亦较术前升高(F时间分别为48.793、53.721、25.970和24.779,P均<0.001),而观察组L6、8和HSP70升高幅度小于对照组(F组间=31.953、59.836和20.479,P均<0.001)。结论:丙泊酚麻醉可减轻肝癌射频消融术患者的伤害性炎性反应。
Abstract:
Aim:To study the effects of propofol anesthesia on serum interleukins(IL) and HSP70 levels in patients with liver cancer after radiofrequency ablation(RFA).Methods:Forty ASA Ⅰ~Ⅱ patients with liver cancer aged 40~65 years would receive RFA were divided into 2 groups (20 in each group).Patients in group P were given propofol to maintain general anesthesia.Patients in group C were given lidocaine to maintain local anesthesia. MBP,HR,SPO2,and temperature were detected at the time of preanesthesia,postanesthesia,heat blocking action,and 1,24 and 48 h after therapy. In addition, serum IL6, IL8,IL10 and HSP70 levels were determined before therapy and at 1,24,and 48 h after therapy by ELISA. Results:The temperature,MBP,and serum HSP70,IL6,IL8,IL10 levels of the two groups increased during RFA (Ftime=291.525,14.007,24.779,48.793,53.721,and 25.970,P<0.001), but the changes of group C was more obvious than group P(P<0.001). Conclusion:Propofol anesthesia can effectively restrain the damaged inflammatory reaction in patients with liver cancer after RFA.

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备注/Memo

备注/Memo:
#通讯作者,男,1977年10月生,博士,主治医师,研究方向:肝癌、临床麻醉,Email:lihan159@126.com
更新日期/Last Update: 2012-08-14