[1]崔文燕),郭明),原园),等.食管鳞状细胞癌组织中23种肿瘤相关蛋白的表达*[J].郑州大学学报(医学版),2012,(05):598.
 CUI Wenyan),GUO Ming),YUAN Yuan),et al.Expressions of 23 kinds of cancerrelated protein in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(05):598.
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食管鳞状细胞癌组织中23种肿瘤相关蛋白的表达*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2012年05期
页码:
598
栏目:
食管癌研究
出版日期:
2012-09-20

文章信息/Info

Title:
Expressions of 23 kinds of cancerrelated protein in esophageal squamous cell carcinoma tissue
作者:
崔文燕12)郭明2)原园2)周福有3)张朋12)王伟鹏4)赵学科2)陈元方5)任景丽6)王立东12)#
1)新乡医学院癌症研究中心 新乡 453003 2)郑州大学第一附属医院河南省食管癌重点开放实验室 郑州 450052 3)安阳肿瘤医院外科 安阳 455000 4)磁县医院病理科 磁县 056500 5)鹤壁市卫生局 鹤壁 458030 6)郑州大学第二附属医院病理科 郑州 450014
Author(s):
CUI Wenyan12)GUO Ming2)YUAN Yuan2)ZHOU Fuyou3)ZHANG Peng12) WANG Weipeng4)ZHAO Xueke2)CHEN Yuanfang5)REN Jingli6)WANG Lidong12)
1)Cancer Research Center, Xinxiang Medical University,Xinxiang 453003 2)Henan Key Laboratory for Esophageal Cancer Research,the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052 3)Department of Surgery, Anyang Tumor Hospital,Anyang 455000 4)Department of Pathology,Cixian Hospital,Cixian 056500 5)Bureau of Health in Hebi City,Hebi 458030 6)Department of Pathology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014
关键词:
食管肿瘤鳞状细胞癌预后肿瘤相关蛋白淋巴结转移分化程度临床分期
Keywords:
esophageal neoplasmsquamous cell carcinomaprognosistumorrelated proteinlymph node metastasisdegree of differentiation clinical stage
分类号:
R735.1
摘要:
目的:探讨食管鳞状细胞癌(食管鳞癌)组织中肿瘤相关蛋白表达与临床病理变化的关系。方法:采用免疫组化法检测679例食管鳞癌组织中细胞骨架结合蛋白Fascin、突触蛋白Syn和肿瘤抑制基因P63等23种肿瘤相关蛋白在癌组织中的表达,分析上述蛋白的表达与临床病理指标(淋巴结转移、分化程度及临床分期等)的关系。结果:23种蛋白中,食管癌组织中阳性表达率较高(≥80%)的蛋白是AE1/AE3、P63、CK5/6、CK、Ki67和MUC1,较低(≤30%)的是CD56、CTTN、Syn、S100、CgA和CK20。其中,Syn在淋巴结有转移组织比无转移组织表达升高(χ2=4.167,P=0.041),免疫蛋白CD56在低分化组织高于中高分化组织(P=0.017),细胞增殖抗原Ki67在中晚期组织高于早期(χ2=6.596,P=0.010);而与此相反,P63则在淋巴结无转移时表达上升(χ2=5.095,P=0.024),细胞黏附因子Ecad、Fascin、Ezrin、PLK1在中高分化组织中表达升高(P均<0.05),酪氨酸磷酸化蛋白CTTN和Vim在早期组织高于中晚期组织(P均<0.05)。结论:Syn、CD56和Ki67高表达可能与食管癌预后差有关;而P63、 Ecad、Fascin、Ezrin、PLK1和Vim、CTTN高表达可能与食管癌预后好有关。
Abstract:
Aim:To detect the expressions of 23 kinds of cancerrelated protein and their relation with clinical pathological changes in 679 cases of esophageal squamous cell carcinoma(ESCC),and to further understand the molecular basis for ESCC prognosis.Methods:Six hundred and seventy nine ESCC samples were surgically resected tissue.The expressions of 23 kinds of cancerrelated protein,including Fascin, Syn,P63,et al were detected by immunohistochemical method.The relationship between the expressions of 23 kinds of protein and clinical pathological changes was analyzed.Results:Out of the 23 kinds of cancerrelated protein,AE1/AE3, P63, CK5/6, CK, Ki67 and MUC1 (≥80%) had relatively higher positive expression rate in ESCC tissue,while CD56, CTTN, Syn, S100, CgA and CK20 (≤30%) had relatively lower positive expression rate.Syn expression was higher in metastasis tissue than in nonmetastasis tissue(χ2=4.167,P=0.041),CD56 expression was higher in poorly differentiated tissue than in high and moderate differentiated tissue (P=0.017),and Ki67 expression was higher in advanced stage than in early stage (χ2=6.596,P=0.010). In contrast,P63 expression was higher in ESCC tissue without metastasis (χ2=5.095,P=0.024),the expressions of Ecad, Fascin, Ezrin,and PLK1 were higher in high and moderate differentiated tissue (P<0.05),and Vim and CTTN protein expression was higher in early stage than in advanced stage(P<0.05).Conclusion:The higher expressions of Syn, CD56 and Ki67 may be important candidates for ESCC with poor prognosis. However, the higher expressions of P63, Ecad, Fascin, Ezrin, PLK1, Vim, and CTTN may be important candidates for ESCC with better prognosis.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目30971133 #通讯作者,男,1958年8月生,博士,教授,研究方向:食管和贲门癌变机制及防治,Email:ldwang2007@126.com
更新日期/Last Update: 1900-01-01